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Fig. 2 | Critical Care

Fig. 2

From: Estrogen administered after cardiac arrest and cardiopulmonary resuscitation ameliorates acute kidney injury in a sex- and age-specific manner

Fig. 2

17β-estradiol exerted a dose-dependent renoprotective effect after cardiac arrest and cardiopulmonary resuscitation (CA/CPR) in young males. Blood and tissue samples were collected 24 h after CA/CPR in young male intravenously injected with 0.5, 5, or 10 μg of 17β-estradiol or vehicle 15 min after return of spontaneous circulation. Post-arrest administration of 17β-estradiol exerted a dose-dependent renoprotective effect. At 0.5 μg, 17β-estradiol administration exerted no apparent effect on renal injury 24 h after CA/CPR. Five micrograms caused significant reduction in serum creatinine (b) but not serum urea nitrogen (a) and necrotic tubules (c). At a dose of 10 μg, 17β-estradiol significantly reduced serum urea nitrogen (a), serum creatinine (b), and necrotic tubules (c) by 41 %, 30 %, and 31 %, respectively. Data are presented as mean ± standard deviation, n = 8–15, *P < 0.05 by two-way analysis of variance with post hoc Sidak’s test. EST 17β-estradiol-treated mice, VEH vehicle-treated mice

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