THAM reduces CO2-associated increase in pulmonary vascular resistance – an experimental study in lung-injured piglets

Table 4 Electrolytes

Parameter	Group	Start	60 min	180 min	360 min
[Na⁺] (mmol/L)	NT	134 (1)	134 (1)	132 (2)	130 (2)
	1T	134 (2)	129 (2)^a	134 (1)	135 (1)^a
	3T	132 (2)^a,b	125 (2)^a,b	125 (2)^a,b	138 (3)^a,b
[K⁺] (mmol/L)	NT	4.3 (0.2)	4.6 (0.2)	5.2 (0.4)	5.5 (0.6)
	1T	4.5 (0.2)	5.1 (0.3)^a	5.0 (0.3)	5.2 (0.4)
	3T	4.3 (0.3)	5.0 (0.3)	5.9 (0.3)^a,b	4.8 (0.5)
[Ca²⁺] (mmol/L)	NT	1.43 (0.17)	1.51 (0.16)	1.35 (0.11)	1.29 (0.11)
	1T	1.43 (0.14)	1.33 (0.19)^a	1.36 (0.14)	1.28 (0.13)
	3T	1.25 (0.06)^b	1.21 (0.04)^a	1.01 (0.06)^a,b	1.09 (0.05)^a,b
[Cl⁻] (mmol/L)	NT	101 (2)	99 (1)	98 (2)	93 (3)
	1T	101 (1)	98 (1)	97 (3)	93 (2)
	3T	104 (3)	99 (1)	96 (2)	94 (2)

Abbreviations: [Ca²⁺] arterial calcium concentration, [Cl⁻] arterial chloride concentration, [K⁺] arterial potassium concentration, [Na⁺] arterial sodium concentration, NT control animals that did not receive THAM, 1T group that received THAM infusion for 1 h, 3T group that received THAM infusion for 3 h, THAM Tris(hydroxymethyl)aminomethane
The time points refer to time after start of THAM infusion or corresponding time points in the controls (NT)
Values are mean (standard deviation)
^aValue is different from NT group
^bValue is different from 1T group

ISSN: 1364-8535