Parameter | Group | Baseline | Start | 60 min | 180 min | 360 min |
---|---|---|---|---|---|---|
MPAP (mmHg) | NT | 18 (3) | 21 (4) | 28 (4) | 28 (4) | 25 (5) |
1T | 19 (2) | 20 (3) | 21 (4)a | 23 (3)a | 21 (2) | |
3T | 14 (2)a,b | 18 (2) | 19 (2)a | 17 (2)a,b | 18 (2)a | |
MAP (mmHg) | NT | 83 (9) | 72 (9) | 68 (9) | 67 (9) | 63 (13) |
1T | 95 (13) | 65 (6) | 67 (17) | 63 (2) | 60 (5) | |
3T | 80 (7) | 62 (5) | 68 (5) | 68 (6) | 69 (6) | |
CI (L/min/m2) | NT | 3.6 (0.5) | 2.4 (0.3) | 2.9 (0.3) | 3.4 (0.7) | 3.5 (1.0) |
1T | 3.4 (0.7) | 2.4 (0.3) | 2.8 (0.4) | 3.8 (0.7) | 3.8 (0.8) | |
3T | 4.2 (1.1) | 2.4 (0.4) | 3.1 (0.5) | 4.2 (0.7) | 5.0 (0.6)a,b | |
PVR (dyn∙s/m5) | NT | 317 (92) | 465 (125) | 572 (85) | 504 (101) | 450 (141) |
1T | 323 (79) | 448 (75) | 423 (113)a | 373 (65)a | 329 (77) | |
3T | 264 (69) | 481 (109) | 373 (103)a | 290 (62)a | 255 (43)a | |
SVR (dyn∙s/m5) | NT | 2240 (515) | 2757 (736) | 2030 (257) | 1720 (297) | 1566 (262) |
1T | 2942 (1201) | 2485 (619) | 2136 (782) | 1517 (283) | 1431 (255) | |
3T | 2147 (716) | 2558 (250) | 2204 (208) | 1725 (276) | 1449 (125) |