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Table 2 Hemodynamics

From: THAM reduces CO2-associated increase in pulmonary vascular resistance – an experimental study in lung-injured piglets

Parameter Group Baseline Start 60 min 180 min 360 min
MPAP (mmHg) NT 18 (3) 21 (4) 28 (4) 28 (4) 25 (5)
1T 19 (2) 20 (3) 21 (4)a 23 (3)a 21 (2)
3T 14 (2)a,b 18 (2) 19 (2)a 17 (2)a,b 18 (2)a
MAP (mmHg) NT 83 (9) 72 (9) 68 (9) 67 (9) 63 (13)
1T 95 (13) 65 (6) 67 (17) 63 (2) 60 (5)
3T 80 (7) 62 (5) 68 (5) 68 (6) 69 (6)
CI (L/min/m2) NT 3.6 (0.5) 2.4 (0.3) 2.9 (0.3) 3.4 (0.7) 3.5 (1.0)
1T 3.4 (0.7) 2.4 (0.3) 2.8 (0.4) 3.8 (0.7) 3.8 (0.8)
3T 4.2 (1.1) 2.4 (0.4) 3.1 (0.5) 4.2 (0.7) 5.0 (0.6)a,b
PVR (dyn∙s/m5) NT 317 (92) 465 (125) 572 (85) 504 (101) 450 (141)
1T 323 (79) 448 (75) 423 (113)a 373 (65)a 329 (77)
3T 264 (69) 481 (109) 373 (103)a 290 (62)a 255 (43)a
SVR (dyn∙s/m5) NT 2240 (515) 2757 (736) 2030 (257) 1720 (297) 1566 (262)
1T 2942 (1201) 2485 (619) 2136 (782) 1517 (283) 1431 (255)
3T 2147 (716) 2558 (250) 2204 (208) 1725 (276) 1449 (125)
  1. Abbreviations: CI cardiac index, MAP mean systemic arterial pressure, MPAP mean pulmonary arterial pressure, NT control animals that did not receive THAM, PVR pulmonary vascular resistance, SVR systemic vascular resistance, 1T group that received THAM infusion for 1 h, 3T group that received THAM infusion for 3 h, THAM Tris(hydroxymethyl)aminomethane
  2. The time points refer to time after start of THAM infusion or corresponding time points in the controls (NT)
  3. Values are mean (standard deviation)
  4. aValue is different from NT group
  5. bValue is different from 1T group