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Table 1 Arterial acid–base values, arterial and venous oxygenation, oxygen consumption, and venous admixture

From: THAM reduces CO2-associated increase in pulmonary vascular resistance – an experimental study in lung-injured piglets

Parameter Group Baseline Start 60 min 180 min 360 min
pH NT 7.40 (0.04) 7.40 (0.01) 7.14 (0.03) 7.11 (0.05) 7.12 (0.06)
1T 7.40 (0.05) 7.41 (0.02) 7.34 (0.05)a 7.18 (0.05)a 7.16 (0.07)
3T 7.43 (0.02) 7.40 (0.01) 7.35 (0.02)a 7.39 (0.01)a,b 7.16 (0.03)
PaCO2 (kPa) NT 6.6 (1.2) 6.0 (0.5) 12.3 (1.2) 13.5 (1.4) 13.8 (1.5)
1T 6.0 (0.6) 5.8 (0.3) 10.2 (0.9)a 14.6 (2.4) 15.2 (3.3)
3T 6.3 (0.7) 5.9 (0.7) 10.6 (0.7)a 13.1 (0.5) 22.6 (1.7)a,b
PaO2 (kPa) NT 62.6 (12.7) 63.7 (7.4) 48.1 (12.0) 45.2 (12.3) 46.4 (11.8)
1T 65.2 (4.8) 65.0 (8.6) 59.8 (6.3) 49.4 (9.0) 53.3 (5.0)
3T 55.5 (15.5) 56.0 (4.6) 49.7 (4.1) 32.6 (7.6)§ 30.0 (7.7)a,b
Base excess (mEq/ml) NT 4.8 (2.2) 2.7 (2.3) 1.3 (2.2) 1.8 (2.8) 3.4 (3.2)
1T 3.0 (3.2) 2.4 (1.5) 13.8 (3.5)a 10.9 (3.1)a 10.2 (2.1)a
3T 6.2 (2.1) 2.4 (3.0) 16.0 (0.6)a 31.2 (2.2)a,b 27.8 (3.1)a,b
HCO3 (mmol/L) NT 28.5 (1.8) 27.2 (2.5) 29.7 (2.2) 30.8 (2.5) 32.3 (2.8)
1T 27.0 (2.8) 26.7 (1.5) 40.1 (3.2)a 39.3 (3.2)a 38.8 (2.5)a
3T 29.8 (1.9) 26.8 (3.1) 42.3 (0.9)a 58.6 (2.2)a,b 57.2 (2.8)a,b
SaO2 (%) NT 98 (0.3) 98 (0.2) 97 (0.4) 97 (0.6) 97 (0.6)
1T 98 (0.2) 98 (0.3) 98 (0.3)a 98 (0.2) 97 (0.2)
3T 98 (0.8) 98 (0.1)c 98 (0.2)a 98 (0.3) 97 (0.8)
SvO2 (%) NT 71 (11) 53 (11) 63 (6.1) 67 (5.8) 67 (11)
1T 68 (4.6) 43 (5.2) 54 (10) 65 (6.5) 66 (10)
3T 70 (7.6) 47 (11)c 61 (7.9) 69 (4.6) 74 (2.1)
VO2 (ml/min) NT 133 (32) 124 (22) 118 (23) 120 (9) 121 (21)
1T 128 (28) 142 (18) 131 (20) 139 (14)c 140 (26)
3T 133 (30)c 123 (18)c 117 (7) 127 (7) 134 (13)
Qs/Qt (fraction) NT 0.15 (0.03) 0.11 (0.04) 0.17 (0.04) 0.20 (0.07) 0.20 (0.08)
1T 0.13 (0.03) 0.09 (0.02) 0.11 (0.03)a 0.17 (0.05)c 0.15 (0.04)
3T 0.16 (0.02)c 0.12 (0.02)c 0.15 (0.03)b 0.24 (0.04) 0.26 (0.06)b
Lactate (mmol/L) NT 1.1 (0.26) 1.3 (0.23) 0.7 (0.08) 0.6 (0.14) 0.6 (0.14)
1T 1.6 (0.81) 1.4 (0.14) 1.1 (0.19)a 0.6 (0.14) 0.7 (0.19)
3T 1.1 (0.32) 1.2 (0.15) 0.9 (0.31) 0.9 (0.23)a 1.3 (0.59)a,b
ΔPaCO2 (kPa) NT 1.5 (0.6) 2.2 (0.6) 1.9 (0.5) 2.2 (0.7) 2.1 (0.8)
1T 1.8 (0.4) 2.6 (0.3) 0.7 (1.1)a 2.1 (0.3) 2.2 (0.6)
3T 1.5 (0.3) 2.7 (0.3) 0.6 (0.4)a 0.2 (0.6)a,b 1.0 (0.7)a,b
  1. Abbreviations: BE arterial base excess, HCO3 arterial bicarbonate concentration, NT control animals that did not receive THAM, PaCO2 arterial carbon dioxide tension, ΔPaCO2 arteriovenous difference in carbon dioxide tension, PaO2 arterial oxygen tension, Qs/Qt venous admixture obtained at inspired oxygen fraction 1.0, SvO2 mixed venous oxygen saturation, 1T group that received THAM infusion for 1 h, 3T group that received THAM infusion for 3 h, THAM Tris(hydroxymethyl)aminomethane, VO2 body oxygen consumption
  2. The time points refer to time after start of THAM infusion or corresponding time points in the controls (NT)
  3. aValue is different from NT group
  4. bValue is different from 1T group
  5. cOnly 5 subjects represented owing to technical error