Descriptive variable | PICU sepsis cohort | ED sepsis cohort | ED control cohort | |||
---|---|---|---|---|---|---|
 | 2–5 yr | 6–17 yr | 2–5 yr | 6–17 yr | 2–5 yr | 6–17 yr |
 | (n =36) | (n =58) | (n =43) | (n =38) | (n =25) | (n =38) |
Age (mo) | 39 (13.8) | 138 (45) | 37 (12.9) | 131 (47) | 45 (13) | 133 (46) |
Males | 18 (50 %) | 34 (59 %) | 20 (47 %) | 18 (47 %) | 16 (64 %) | 28 (74 %) |
Weight (kg) | 14.4 (4.5) | 40.2 (20.5) | 15.6 (3.4) | 41.3 (22.5) | 17.2 (3.0) | 45.7 (17.6) |
Underlying comorbidity | Â | Â | Â | Â | N/A | N/A |
 Neuromuscular | 10 (28 %) | 21 (36 %) | 3 (7 %) | 4 (11 %) | ||
 Cardiac | 9 (25 %) | 7 (12 %) | 0 | 1 (3 %) | ||
 Respiratory | 5 (14 %) | 12 (21 %) | 2 (5 %) | 0 | ||
PRISM III score | 11 (9); 10 [2–18] | 8 (7); 7 [3–11] | N/A | N/A | N/A | N/A |
PELOD score | 16.7 (9.4); 13 [11–22] | 11.5 (7.6); 12 [10–13] | N/A | N/A | N/A | N/A |
WBC count (109/Litre) | 12.9 (10.3) | 13.6 (8,7) | 12.8 (7.9); n =39 | 13.7 (7.2) | N/A | N/A |
Platelet count (109/Litre) | 185 (124) | 191 (127) | 277 (99); n =39 | 252 (93) | N/A | N/A |
Creatinine (μmol/L) | 53 (48) | 60 (39) | 28 (7); n =30 | 47 (19); n =30 | N/A | N/A |
Lactate (mmol/L) | 2.1 (1.9) | 2.4 (2.5) | 1.3 [1.2–1.6]; n =13 | 1.2 [1.0–2.0]; n =8 | N/A | N/A |
Lowest SBP (mmHg) | 77 (13) | 92 (17) | 96 (13) | 106 (11) | 104 (14) | 121 (12) |
Lowest MAP (mmHg) | 54 (8) | 63 (13) | – | – | – | – |
pH | 7.3 (0.1) | 7.3 (0.1) | – | – | – | – |
Sepsis developed after first PICU day | 6 (17 %) | 4 (7 %) | N/A | N/A | N/A | N/A |
Site of infection | Â | Â | Â | Â | N/A | N/A |
 Pneumonia without microbiological confirmation | 21 (58 %) | 28 (48 %) | 23 (53 %) | 11 (29 %) | – | – |
 Microbiologically confirmed (culture positive) | 15 (42 %)a | 30 (52 %)b | 12 (28 %)c | 19 (50 %)d | – | – |
 Clinically diagnosed | 0 (0 %) | 0 (0 %) | 8 (19 %)c | 8 (21 %)d | – | – |
Mechanical ventilation on first day | 27 (75 %) | 38 (67 %) | N/A | N/A | N/A | N/A |
Inotrope/vasopressor infusion on first day | 20 (56 %) | 34 (57 %) | N/A | N/A | N/A | N/A |
Duration of mechanical ventilation after enrollment (days) | n =28 | n =42 | N/A | N/A | N/A | N/A |
(78 %) | (69 %) | |||||
10 [5–13] | 6 [3–8] | |||||
PICU length of stay after enrollment (days) | <2 days: 2 (6 %) | <2 days: 4 (7 %) | Hospital stay | Hospital stay | N/A | N/A |
8 [3–15] | 7 [3–10] | 4 [3, 5]; n =20 | 4 [3, 6]; n =19 | |||
RRT | 4 (11 %) | 2 (4 %) | 0 | 0 | N/A | N/A |
ECLS therapy | 6 (17 %) | 4 (7 %) | 0 | 0 | N/A | N/A |
PICU mortality | 1 (3 %) | 1 (2 %) | 0 | 0 | 0 | 0 |