| Control | SIRS | Sepsis | Severe sepsis | Septic shock | P value |
---|---|---|---|---|---|---|
Number | 50 | 59 | 93 | 71 | 63 | Â |
Age, years | 68 (66−74) | 70 (59−78) | 71 (66−78) | 73 (62−77) | 74 (64−79) | 0.34 |
Male, % | 62.0 | 57.6 | 60.2 | 63.4 | 60.3 | 0.97 |
WBC, ×109/L | 6.6 (5.6−7.6) | 9.2 (8.1−11.6) | 11.9 (9.6−14.2) | 14.9 (10.9−17.7) | 16.6 (13.5−19.6) | <0.001 |
Lymphocytes, ×109/L | 2.8 (2.4−3.1) | 1.4 (1.0−1.7) | 1.1 (0.9−1.7) | 0.8(0.5−1.2) | 0.6 (0.4−0.9) | <0.001 |
PCT, g/ml | 0.06 (0.05−0.1) | 0.2 (0.05−0.3) | 1.0 (0.2−2.1) | 4.6 (0.9−8.1) | 8.3 (1.8−22.3) | <0.001 |
MEDS score | 0 | 5 (3−7) | 9 (6.5−11) | 12 (9−16) | 19 (16−23) | <0.001 |
Percentage of BTLA+/CD4+T cells | ||||||
 | 90.3 (85.6−91.9) | 91.3 (89.0−93.2) | 88.4 (81.9−91.3) | 86.5 (78.6−90.1) | 79.5 (63.6−86.6) | <0.001 |
MFI of BTLA on CD4+ T cells | ||||||
 | 7.2 (6.0−8.1) | 10.2 (8.7−13.3) | 8.7 (7.0−11.0) | 7.6 (6.2−8.9) | 6.5 (4.9−8.7) | <0.001 |
Diagnosis (number) | ||||||
Respiratory | Â | AECOPD (27) | Pneumonia (58) | Pneumonia (58) | Pneumonia (58) | 0.80 |
Asthma (14) | ||||||
Abdominal | Â | Pancreatitis (8) | IAI (17) | IAI (13) | IAI (11) | 0.88 |
Urinary | Â | Â | Pyelonephritis (4) | Pyelonephritis (7) | Pyelonephritis (4) | 0.36 |
Cerebral | Â | Stroke (4) | Meningitis (9) | Meningitis (5) | Meningitis (9) | 0.44 |
Others | Â | DKA (6) | Skin/soft tissue infection (5) | Â | Â | Â |
28-day mortality, number (%) | 5 (8.5 %) | 18 (19.5 %) | 33 (46.5 %) | 37 (58.7 %) | <0.001 |