Skip to main content

Table 1 Baseline characteristics of the study population

From: Low B and T lymphocyte attenuator expression on CD4+ T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study

 

Control

SIRS

Sepsis

Severe sepsis

Septic shock

P value

Number

50

59

93

71

63

 

Age, years

68 (66−74)

70 (59−78)

71 (66−78)

73 (62−77)

74 (64−79)

0.34

Male, %

62.0

57.6

60.2

63.4

60.3

0.97

WBC, ×109/L

6.6 (5.6−7.6)

9.2 (8.1−11.6)

11.9 (9.6−14.2)

14.9 (10.9−17.7)

16.6 (13.5−19.6)

<0.001

Lymphocytes, ×109/L

2.8 (2.4−3.1)

1.4 (1.0−1.7)

1.1 (0.9−1.7)

0.8(0.5−1.2)

0.6 (0.4−0.9)

<0.001

PCT, g/ml

0.06 (0.05−0.1)

0.2 (0.05−0.3)

1.0 (0.2−2.1)

4.6 (0.9−8.1)

8.3 (1.8−22.3)

<0.001

MEDS score

0

5 (3−7)

9 (6.5−11)

12 (9−16)

19 (16−23)

<0.001

Percentage of BTLA+/CD4+T cells

 

90.3 (85.6−91.9)

91.3 (89.0−93.2)

88.4 (81.9−91.3)

86.5 (78.6−90.1)

79.5 (63.6−86.6)

<0.001

MFI of BTLA on CD4+ T cells

 

7.2 (6.0−8.1)

10.2 (8.7−13.3)

8.7 (7.0−11.0)

7.6 (6.2−8.9)

6.5 (4.9−8.7)

<0.001

Diagnosis (number)

Respiratory

 

AECOPD (27)

Pneumonia (58)

Pneumonia (58)

Pneumonia (58)

0.80

Asthma (14)

Abdominal

 

Pancreatitis (8)

IAI (17)

IAI (13)

IAI (11)

0.88

Urinary

  

Pyelonephritis (4)

Pyelonephritis (7)

Pyelonephritis (4)

0.36

Cerebral

 

Stroke (4)

Meningitis (9)

Meningitis (5)

Meningitis (9)

0.44

Others

 

DKA (6)

Skin/soft tissue infection (5)

   

28-day mortality, number (%)

5 (8.5 %)

18 (19.5 %)

33 (46.5 %)

37 (58.7 %)

<0.001

  1. Data are shown as median and interquartile range (IQR) unless stated otherwise. WBC white blood cells, PCT procalcitonin, MEDS Mortality in Emergency Department Sepsis, BTLA B and T lymphocyte attenuator, MFI mean of fluorescence intensities, AECOPD acute exacerbation of chronic obstructive pulmonary disease, IAI intraabdominal infection, DKA diabetic ketoacidosis, ED Emergency Department, SIRS systemic inflammatory response syndrome