| |
Control
|
SIRS
|
Sepsis
|
Severe sepsis
|
Septic shock
|
P value
|
|---|
|
Number
|
50
|
59
|
93
|
71
|
63
| |
|
Age, years
|
68 (66−74)
|
70 (59−78)
|
71 (66−78)
|
73 (62−77)
|
74 (64−79)
|
0.34
|
|
Male, %
|
62.0
|
57.6
|
60.2
|
63.4
|
60.3
|
0.97
|
|
WBC, ×109/L
|
6.6 (5.6−7.6)
|
9.2 (8.1−11.6)
|
11.9 (9.6−14.2)
|
14.9 (10.9−17.7)
|
16.6 (13.5−19.6)
|
<0.001
|
|
Lymphocytes, ×109/L
|
2.8 (2.4−3.1)
|
1.4 (1.0−1.7)
|
1.1 (0.9−1.7)
|
0.8(0.5−1.2)
|
0.6 (0.4−0.9)
|
<0.001
|
|
PCT, g/ml
|
0.06 (0.05−0.1)
|
0.2 (0.05−0.3)
|
1.0 (0.2−2.1)
|
4.6 (0.9−8.1)
|
8.3 (1.8−22.3)
|
<0.001
|
|
MEDS score
|
0
|
5 (3−7)
|
9 (6.5−11)
|
12 (9−16)
|
19 (16−23)
|
<0.001
|
|
Percentage of BTLA+/CD4+T cells
|
| |
90.3 (85.6−91.9)
|
91.3 (89.0−93.2)
|
88.4 (81.9−91.3)
|
86.5 (78.6−90.1)
|
79.5 (63.6−86.6)
|
<0.001
|
|
MFI of BTLA on CD4+ T cells
|
| |
7.2 (6.0−8.1)
|
10.2 (8.7−13.3)
|
8.7 (7.0−11.0)
|
7.6 (6.2−8.9)
|
6.5 (4.9−8.7)
|
<0.001
|
|
Diagnosis (number)
|
|
Respiratory
| |
AECOPD (27)
|
Pneumonia (58)
|
Pneumonia (58)
|
Pneumonia (58)
|
0.80
|
|
Asthma (14)
|
|
Abdominal
| |
Pancreatitis (8)
|
IAI (17)
|
IAI (13)
|
IAI (11)
|
0.88
|
|
Urinary
| | |
Pyelonephritis (4)
|
Pyelonephritis (7)
|
Pyelonephritis (4)
|
0.36
|
|
Cerebral
| |
Stroke (4)
|
Meningitis (9)
|
Meningitis (5)
|
Meningitis (9)
|
0.44
|
|
Others
| |
DKA (6)
|
Skin/soft tissue infection (5)
| | | |
|
28-day mortality, number (%)
|
5 (8.5 %)
|
18 (19.5 %)
|
33 (46.5 %)
|
37 (58.7 %)
|
<0.001
|
- Data are shown as median and interquartile range (IQR) unless stated otherwise. WBC white blood cells, PCT procalcitonin, MEDS Mortality in Emergency Department Sepsis, BTLA B and T lymphocyte attenuator, MFI mean of fluorescence intensities, AECOPD acute exacerbation of chronic obstructive pulmonary disease, IAI intraabdominal infection, DKA diabetic ketoacidosis, ED Emergency Department, SIRS systemic inflammatory response syndrome
