From: The role of previously unmeasured organic acids in the pathogenesis of severe malaria
Characteristics | Uncomplicated malaria N=102 | Severe malaria N=138 | Sepsis N=32 | Encephalopathy N=35 | P value* | ||||
---|---|---|---|---|---|---|---|---|---|
Male, n (%) | 80 | (78 %) | 97 | (70 %) | 15 | (47 %) | 23 | (66 %) | 0.008 |
Age, yr, mean (SD, range) | 33 | (14.8, 16–70) | 36 | (14.2, 16–75) | 37 | (14.7, 16–70) | 40 | (18.4, 18–75) | 0.106 |
Respiratory rate, breaths/min, mean (SD, range) | 26 | (6.6, 18–48) | 32 | (10.2, 15–93) | 34 | (9.9, 15–58) | 30 | (9.4, 12–60) | <0.001 |
Heart rate, beats/min, mean (SD, range) | 95 | (16.2, 64–149) | 110 | (22.5, 54–166) | 120 | (16.9, 92–151) | 104 | (24.7, 60–170) | <0.001 |
Mean arterial pressure, mmHg, mean (SD, range) | 81 | (11.7, 57–115) | 83 | (15.2, 28–144) | 79 | (19.3, 20–127) | 93 | (17.1, 64–125) | <0.001 |
Shock, SBP <80 mmHg, n (%) | 0 | (0 %) | 2 | (1.4 %) | 6 | (19 %) | 0 | (0 %) | Â |
Glasgow Coma Scale score, geo mean (95 % CI) | 15 | (15–15) | 9 | (9–10) | 11 | (9–13) | 7 | (6–8) | <0.001 |
 GCS score <15, n (%) | 15/102 | (15 %) | 109/138 | (79 %) | 17/32 | (53 %) | 35/35 | (100 %) |  |
 GCS score <11, n (%) | 0 | (0 %) | 87/138 | (63 %) | 10/32 | (31 %) | 35/35 | (100 %) |  |
 GCS score <8, n (%) | 0 | (0 %) | 28/138 | (20 %) | 7/32 | (22 %) | 10/35 | (29 %) |  |
Parasitaemia (count/μl), geo mean (95 % CI) | 11,184 | (6853–18,253) | 27,933 | (18,101–43,105) |  |  |  |  | 0.007 |
PfHRP2 (ng/ml), geo mean (95 % CI)a | 274 | (201–376) | 1,684 | (1,323–2,143) |  |  |  |  | <0.001 |
Total bilirubin (mg/dl), geo mean (95 % CI, range) | 1.1 | (0.9–1.4, 0.2–28.3) | 2.8 | (2.3–3.5, 0.2–44.2) | 0.94 | (0.6–1.5, 0.2–10.9) | 0.47 | (0.3–0.6, 0.1–6.0) | <0.001 |
Creatinine (mg/dl), geo mean (95 % CI, range) | 1.0 | (0.9–1.0, 0.5–2.3) | 1.5 | (1.3–1.7, 0.5–8.6) | 1.7 | (1.2–2.3,0.3–14.1) | 1.1 | (0.9–1.4, 0.6–24.3) | <0.001 |
Acute kidney injury (creatinine >3 mg/dl) | 0/101 | (0 %) | 20/135 | (15 %) | 6/31 | (19 %) | 2/35 | (6 %) | Â |
Hb (g/dl), mean (SD, range) | 10.6 | (2.8, 3.8–15.6) | 9.6 | (3.1, 2.6–17.5) | 10.3 | (3.0, 5.0–16.7) | 12.3 | (2.5, 4.7–16.1) | <0.001 |
Anaemia (Hb <7 g/dl), n (%) | 13 | (13 %) | 24 | (17 %) | 3 | (9 %) | 2 | (6 %) | Â |
Glucose (mg/dl), geo mean (95 % CI, range) | 122 | (114–130, 55–332) | 124 | (115–134, 33–455) | 126 | (104–152, 39–443) | 146 | (124–171, 63–612) | 0.205 |
Hypoglycaemia (<40 mg/dl), n (%) | 0 | (0 %) | 3 | (2 %) | 1 | (3 %) | 0 | (0 %) | Â |
Mortality, n (%) | 0 | (0 %) | 39 | (28 %) | 16 | (50 %) | 15 | (43 %) | <0.001 |