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Table 1 Comparison of patient characteristics, severity at ICU admission, microbiological data, and therapeutic measures between patients treated with rifampin or not for community-acquired bacterial meningitis (n=157)

From: Rifampin use in acute community-acquired meningitis in intensive care units: the French retrospective cohort ACAM-ICU study

Characteristics Rifampin No rifampin p Value
n=32 n=125
Demographic data   IQR   IQR  
 Age, yr 41.4 [28.7–59.4] 51.1 [34.6–69.3] 0.087
 Female sex 12/32 37.5 % 48/125 38.4 % NS
 Immunosuppression 6/32 18.8 % 23/125 18.4 % NS
 Alcohol use disorder 4/31 12.9 % 14/124 11.3 % NS
 Asplenia 1/32 3.1 % 5/124 4.0 % NS
 HIV infection 1/32 3.1 % 7/124 5.6 % NS
Severity at ICU admission
 Glasgow Coma Scale score 11 [8–14] 12 [7–15] NS
 Mechanical ventilation 11/25 44.0 % 49/111 44.1 % NS
 Severe sepsis or septic shock 21/25 84.0 % 94/111 84.7 % NS
 SAPS II 29 [16–43] 30 [20–48] NS
 LOD system      
  Neurologic 14/25 56.0 % 68/111 61.3 % NS
  Pulmonary 11/25 44.0 % 49/111 44.1 % NS
  Hematologic 11/25 44.0 % 46/111 41.4 % NS
  Cardiovascular 12/25 48.0 % 38/111 34.2 % NS
  Renal 5/25 20.0 % 27/111 24.3 % NS
  Hepatic    
Microbiology
 CSF white cell count/mm3 1710 [450–5100] 1820 [315–3300] NS
 CSF protein rate, g/L 3.8 [2–5.9] 2.7 [1.5–5.8] NS
 Positive direct examination of CSF 21/32 65.6 % 80/120 66.7 % NS
Streptococcus pneumoniae as causative bacterium 20/32 62.5 % 56/125 44.8 % 0.079
  Penicillin non-susceptible isolates 11/20 55,0 % 21/46 45,7 % NS
Neisseria meningitidis as causative bacterium 5/32 15.6 % 39/125 31.2 % 0.081
Therapeutic measures
 Time between hospital admission and first dose of antibiotic (h) 2.5 [0.8–6.1] 3.2 [1.5–6.9] NS
 Treatment with corticosteroids during hospitalization 28/32 87.5 % 77/125 61.6 % 0.006
  1. SAPS II Simplified Acute Physiology Score II, CSF cerebrospinal fluid, LOD Logistic Organ Dysfunction system, NS not significant
  2. Data are proportion of patients or median values [interquartile range]
  3. p Values <0.2 are detailed. p Values <0.05 were considered significant (bold)