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Table 1 ACTH Test 1 and 2 classified according to groups of Δ cortisol <, ≥ 250 nmol/L

From: Erratum to: Diminished adrenal sensitivity to endogenous and exogenous adrenocorticotropic hormone in critical illness: a prospective cohort study

  Test 1 Δ<250 nmol/L Test 1 Δ≥250 nmol/L Test 2 Δ<250 nmol/L Test 2 Δ≥250 nmol/L P Δ cortisol, time, interaction
n=17 n=42 n=14 n=45
ACTH, pmol/L 3.1 (1.1–18.0) 1.5 (1.1–15.0) 6.0 (1.1–14.0) 3.8 (1.0–8.9) 0.001, 0.025, 0.72
Baseline cortisol, nmol/L 470 (200–1355) 430 (75–2670) 655 (335–1890) 495 (35–2670) 0.021, 0.12, 0.30
Baseline cortisol/ACTH, nmol/pmol 148 (36–250) 238 (14–2054) 109 (48–1718) 126 (35–2054) 0.029, 0.16, 0.14
Baseline free cortisol, nmol/L 77 (63–357) (n=9) 86 (38–256) (n=14) 154 (114–252) (n=6) 75 (4–151) (n=20) 0.001, 0.91, 0.19
Baseline free cortisol/ACTH, nmol/pmol 22 (9–38) 39 (16–89) 26 (11–43) 17 (4–35) 0.042, 0.10, <0.001
Δ cortisol, nmol/L 140 (−50–245) 388 (260–4015) 177 (−80–230) 425 (255–965) n.a., 0.45, 0.093
Δ free cortisol, nmol/L 59 (−71–124) 151 (74–678) 40 (−34–99) 133 (32–233) <0.001, 0.15, 0.16
CBG, mg/L 23 (6–43) 29 (13–63) 39 (4–60) 41 (21–65) 0.060, <0.001, 0.90
Albumin, g/L 13 (6–32) 17 (6–24) 16 (12–28) 20 (8–32) 0.25, <0.001, 0.89
Days from admission - test 1 (0–50) 3 (0–44) 25 (9–49) 20 (9–83) 0.57*, 0.15*
Days between tests n.a. n.a. 18 (8–34) 16 (8–43) 0.41*
Days after stop hydrocortisone n.a. n.a. 7 (5–12) 7 (5–14) 0.75*
  1. Median (range); ACTH: adrenocorticotropic hormone, CBG: cortisol binding globulin. *Mann–Whitney U test, otherwise generalized estimating equations; n.a.: not applicable