TY - JOUR AU - Angus, D. C. AU - Poll, T. PY - 2013 DA - 2013// TI - Severe sepsis and septic shock JO - N Engl J Med VL - 369 ID - Angus2013 ER - TY - JOUR AU - Hall, M. J. AU - Williams, S. N. AU - DeFrances, C. J. AU - Golosinskiy, A. PY - 2011 DA - 2011// TI - Inpatient care for septicemia or sepsis: a challenge for patients and hospitals JO - NCHS Data Brief VL - 62 ID - Hall2011 ER - TY - JOUR AU - Martin, G. S. AU - Mannino, D. M. AU - Eaton, S. AU - Moss, M. PY - 2003 DA - 2003// TI - The epidemiology of sepsis in the United States from 1979 through 2000 JO - N Engl J Med VL - 348 ID - Martin2003 ER - TY - JOUR AU - Angus, D. C. AU - Linde-Zwirble, W. T. AU - Lidicker, J. AU - Clermont, G. AU - Carcillo, J. AU - Pinsky, M. R. PY - 2001 DA - 2001// TI - Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care JO - Crit Care Med VL - 29 ID - Angus2001 ER - TY - JOUR AU - Danai, P. AU - Martin, G. S. PY - 2005 DA - 2005// TI - Epidemiology of sepsis: recent advances JO - Curr Infect Dis Rep VL - 7 ID - Danai2005 ER - TY - JOUR AU - Winters, B. D. AU - Eberlein, M. AU - Leung, J. AU - Needham, D. M. AU - Pronovost, P. J. AU - Sevransky, J. E. PY - 2010 DA - 2010// TI - Long-term mortality and quality of life in sepsis: a systematic review JO - Crit Care Med VL - 38 ID - Winters2010 ER - TY - JOUR AU - Rivers, E. AU - Nguyen, B. AU - Havstad, S. AU - Ressler, J. AU - Muzzin, A. AU - Knoblich, B. PY - 2001 DA - 2001// TI - Early goal-directed therapy in the treatment of severe sepsis and septic shock JO - N Engl J Med VL - 345 ID - Rivers2001 ER - TY - JOUR AU - Dellinger, R. P. AU - Levy, M. M. AU - Rhodes, A. AU - Annane, D. AU - Gerlach, H. AU - Opal, S. M. PY - 2013 DA - 2013// TI - Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012 JO - Crit Care Med VL - 41 ID - Dellinger2013 ER - TY - JOUR AU - Marik, P. E. PY - 2014 DA - 2014// TI - Early management of severe sepsis: concepts and controversies JO - Chest VL - 145 ID - Marik2014 ER - TY - JOUR AU - Vazquez-Guillamet, C. AU - Scolari, M. AU - Zilberberg, M. D. AU - Shorr, A. F. AU - Micek, S. T. AU - Kollef, M. PY - 2014 DA - 2014// TI - Using the number needed to treat to assess appropriate antimicrobial therapy as a determinant of outcome in severe sepsis and septic shock JO - Crit Care Med VL - 42 ID - Vazquez-Guillamet2014 ER - TY - JOUR AU - Marik, P. E. AU - Baram, M. AU - Vahid, B. PY - 2008 DA - 2008// TI - Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares JO - Chest VL - 134 ID - Marik2008 ER - TY - JOUR AU - McGee, D. C. AU - Gould, M. K. PY - 2003 DA - 2003// TI - Preventing complications of central venous catheterization JO - N Engl J Med VL - 348 ID - McGee2003 ER - TY - JOUR AU - Levy, M. M. AU - Fink, M. P. AU - Marshall, J. C. AU - Abraham, E. AU - Angus, D. AU - Cook, D. PY - 2003 DA - 2003// TI - 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference JO - Crit Care Med VL - 31 ID - Levy2003 ER - TY - JOUR AU - King, E. G. AU - Bauzá, G. J. AU - Mella, J. R. AU - Remick, D. G. PY - 2014 DA - 2014// TI - Pathophysiologic mechanisms in septic shock JO - Lab Invest VL - 94 ID - King2014 ER - TY - JOUR AU - Vincent, J. L. AU - Zhang, H. AU - Szabo, C. AU - Preiser, J. C. PY - 2000 DA - 2000// TI - Effects of nitric oxide in septic shock JO - Am J Respir Crit Care Med VL - 161 ID - Vincent2000 ER - TY - JOUR AU - Kirkeboen, K. A. AU - Strand, O. A. PY - 1999 DA - 1999// TI - The role of nitric oxide in sepsis – an overview JO - Acta Anaesthesiol Scand VL - 43 ID - Kirkeboen1999 ER - TY - JOUR AU - Zanotti-Cavazzoni, S. L. AU - Hollenberg, S. M. PY - 2009 DA - 2009// TI - Cardiac dysfunction in severe sepsis and septic shock JO - Curr Opin Crit Care VL - 15 ID - Zanotti-Cavazzoni2009 ER - TY - JOUR AU - Astiz, M. E. AU - DeGent, G. E. AU - Lin, R. Y. AU - Rackow, E. C. PY - 1995 DA - 1995// TI - Microvascular function and rheologic changes in hyperdynamic sepsis JO - Crit Care Med VL - 23 ID - Astiz1995 ER - TY - JOUR AU - Lush, C. W. AU - Kvietys, P. R. PY - 2000 DA - 2000// TI - Microvascular dysfunction in sepsis JO - Microcirculation VL - 7 ID - Lush2000 ER - TY - JOUR AU - Backer, D. AU - Creteur, J. AU - Preiser, J. C. AU - Dubois, M. J. AU - Vincent, J. L. PY - 2002 DA - 2002// TI - Microvascular blood flow is altered in patients with sepsis JO - Am J Respir Crit Care Med VL - 166 ID - Backer2002 ER - TY - JOUR AU - Glassford, N. J. AU - Eastwood, G. M. AU - Bellomo, R. PY - 2014 DA - 2014// TI - Physiological changes after fluid bolus therapy in sepsis: a systematic review of the contemporary literature JO - Crit Care VL - 18 ID - Glassford2014 ER - TY - JOUR AU - Kumar, A. AU - Roberts, D. AU - Wood, K. E. AU - Light, B. AU - Parrillo, J. E. AU - Sharma, S. PY - 2006 DA - 2006// TI - Duration of hypotension prior to initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock JO - Crit Care Med VL - 34 ID - Kumar2006 ER - TY - JOUR AU - Gaieski, D. F. AU - Mikkelsen, M. E. AU - Band, R. A. AU - Pines, J. M. AU - Massone, R. AU - Furia, F. F. PY - 2010 DA - 2010// TI - Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department JO - Crit Care Med VL - 38 ID - Gaieski2010 ER - TY - JOUR AU - Daniels, R. PY - 2011 DA - 2011// TI - Surviving the first hours in sepsis: getting the basics right (an intensivist’s perspective) JO - J Antimicrob Chemother VL - 66 ID - Daniels2011 ER - TY - JOUR AU - Gao, F. AU - Melody, T. AU - Daniels, D. F. AU - Giles, S. AU - Fox, S. PY - 2005 DA - 2005// TI - The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study JO - Crit Care VL - 9 ID - Gao2005 ER - TY - JOUR AU - Sebat, F. AU - Johnson, D. AU - Musthafa, A. A. AU - Watnik, M. AU - Moore, S. AU - Henry, K. PY - 2005 DA - 2005// TI - A multidisciplinary community hospital program for early and rapid resuscitation of shock in nontrauma patients JO - Chest VL - 127 ID - Sebat2005 ER - TY - JOUR AU - Micek, S. T. AU - Roubinian, N. AU - Heuring, T. AU - Bode, M. AU - Williams, J. AU - Harrison, C. PY - 2006 DA - 2006// TI - Before-after study of a standardized hospital order set for the management of septic shock JO - Crit Care Med VL - 34 ID - Micek2006 ER - TY - JOUR AU - Kortgen, A. AU - Niederprum, P. AU - Bauer, M. PY - 2006 DA - 2006// TI - Implementation of an evidence-based ‘standard operating procedure’ and outcome in septic shock JO - Crit Care Med VL - 34 ID - Kortgen2006 ER - TY - JOUR AU - Shapiro, N. I. AU - Howell, M. D. AU - Talmor, D. AU - Lahey, D. AU - Ngo, L. AU - Buras, J. PY - 2006 DA - 2006// TI - Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol JO - Crit Care Med VL - 34 ID - Shapiro2006 ER - TY - JOUR AU - Trzeciak, S. AU - Dellinger, R. P. AU - Abate, N. L. AU - Cowan, R. M. AU - Stauss, M. AU - Kilgannon, J. H. PY - 2006 DA - 2006// TI - Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department JO - Chest VL - 129 ID - Trzeciak2006 ER - TY - JOUR AU - Nguyen, H. B. AU - Corbett, S. W. AU - Steele, R. AU - Banta, J. AU - Clark, R. T. AU - Hayes, S. R. PY - 2007 DA - 2007// TI - Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality JO - Crit Care Med VL - 35 ID - Nguyen2007 ER - TY - JOUR AU - Jones, A. E. AU - Focht, A. AU - Horton, J. M. AU - Kline, J. A. PY - 2007 DA - 2007// TI - Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock JO - Chest VL - 132 ID - Jones2007 ER - TY - JOUR AU - Ferrer, R. AU - Artigas, A. AU - Levy, M. M. AU - Blanco, J. AU - González-Díaz, G. AU - Garnacho-Montero, J. PY - 2008 DA - 2008// TI - Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain JO - JAMA VL - 299 ID - Ferrer2008 ER - TY - JOUR AU - Puskarich, M. A. AU - Marchick, M. R. AU - Kline, J. A. AU - Steuerwald, M. T. AU - Jones, A. E. PY - 2009 DA - 2009// TI - One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study JO - Crit Care VL - 13 ID - Puskarich2009 ER - TY - JOUR AU - Girardis, M. AU - Rinaldi, L. AU - Donno, L. AU - Marietta, M. AU - Codeluppi, M. AU - Marchegiano, P. PY - 2009 DA - 2009// TI - Effects on management and outcome of severe sepsis and septic shock patients admitted to the intensive care unit after implementation of a sepsis program: a pilot study JO - Crit Care VL - 13 ID - Girardis2009 ER - TY - JOUR AU - Thiel, S. W. AU - Asghar, M. F. AU - Micek, S. T. AU - Reichley, R. M. AU - Doherty, J. A. AU - Kollef, M. H. PY - 2009 DA - 2009// TI - Hospital-wide impact of a standardized order set for the management of bacteremic severe sepsis JO - Crit Care Med VL - 37 ID - Thiel2009 ER - TY - JOUR AU - Castellanos-Ortega, A. AU - Suberviola, B. AU - García-Astudillo, L. A. AU - Holanda, M. S. AU - Ortiz, F. AU - Llorca, J. PY - 2010 DA - 2010// TI - Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study JO - Crit Care Med VL - 38 ID - Castellanos-Ortega2010 ER - TY - JOUR AU - Cardoso, T. AU - Carneiro, A. H. AU - Ribeiro, O. AU - Teixeira-Pinto, A. AU - Costa-Pereira, A. PY - 2010 DA - 2010// TI - Reducing mortality in severe sepsis with the implementation of a core 6-hour bundle: results from the Portuguese community-acquired sepsis study (SACiUCI study) JO - Crit Care VL - 14 ID - Cardoso2010 ER - TY - JOUR AU - Nguyen, H. B. AU - Kuan, W. S. AU - Batech, M. AU - Shrikhande, P. AU - Mahadevan, M. AU - Li, C. H. PY - 2011 DA - 2011// TI - Outcome effectiveness of the severe sepsis resuscitation bundle with addition of lactate clearance as a bundle item: a multi-national evaluation JO - Crit Care VL - 15 ID - Nguyen2011 ER - TY - JOUR AU - Westphal, G. A. AU - Koenig, Á. AU - Caldeira Filho, M. AU - Feijó, J. AU - Oliveira, L. T. AU - Nunes, F. PY - 2011 DA - 2011// TI - Reduced mortality after the implementation of a protocol for the early detection of severe sepsis JO - J Crit Care VL - 26 ID - Westphal2011 ER - TY - JOUR AU - Castellanos-Ortega, A. AU - Suberviola, B. AU - Garcia-Astudillo, L. A. AU - Ortiz, F. AU - Llorca, J. AU - Delgado-Rodriguez, M. PY - 2011 DA - 2011// TI - Late compliance with the sepsis resuscitation bundle: impact on mortality JO - Shock VL - 36 ID - Castellanos-Ortega2011 ER - TY - JOUR AU - Shiramizo, S. C. AU - Marra, A. R. AU - Durao, M. S. AU - Paes, A. T. AU - Edmond, M. B. AU - Santos, O. F. PY - 2011 DA - 2011// TI - Decreasing mortality in severe sepsis and septic shock patients by implementing a sepsis bundle in a hospital setting JO - PLoS VL - 6 ID - Shiramizo2011 ER - TY - JOUR AU - Sivayoham, N. AU - Rhodes, A. AU - Jaiganesh, T. AU - Zyl, S. N. AU - Elkhodhair, S. AU - Krishnanandan, S. PY - 2012 DA - 2012// TI - Outcomes from implementing early goal-directed therapy for severe sepsis and septic shock: a 4-year observational cohort study JO - Eur J Emerg Med VL - 19 ID - Sivayoham2012 ER - TY - JOUR AU - Jeon, K. AU - Shin, T. G. AU - Sim, M. S. AU - Suh, G. Y. AU - Lim, S. Y. AU - Song, H. G. PY - 2012 DA - 2012// TI - Improvements in compliance with resuscitation bundles and achievement of end points after an educational program on the management of severe sepsis and septic shock JO - Shock VL - 37 ID - Jeon2012 ER - TY - JOUR AU - Miller, R. R. AU - Dong, L. AU - Nelson, N. C. AU - Brown, S. M. AU - Kuttler, K. G. AU - Probst, D. R. PY - 2013 DA - 2013// TI - Multicenter implementation of a severe sepsis and septic shock treatment bundle JO - Am J Respir Crit Care Med VL - 188 ID - Miller2013 ER - TY - JOUR AU - Levy, M. M. AU - Rhodes, A. AU - Phillips, G. S. AU - Townsend, S. R. AU - Schorr, C. A. AU - Beale, R. PY - 2014 DA - 2014// TI - Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study JO - Crit Care Med VL - 40 ID - Levy2014 ER - TY - JOUR AU - Gluud, L. L. PY - 2006 DA - 2006// TI - Bias in clinical intervention research JO - Am J Epidemiol VL - 163 ID - Gluud2006 ER - TY - JOUR AU - Huang, D. T. AU - Angus, D. C. AU - Barnato, A. AU - Gunn, S. R. AU - Kellum, J. A. AU - Stapleton, D. K. PY - 2013 DA - 2013// TI - Harmonizing international trials of early goal-directed resuscitation for severe sepsis and septic shock: methodology of ProCESS, ARISE, and ProMISe JO - Intensive Care Med VL - 39 ID - Huang2013 ER - TY - JOUR AU - Yealy, D. M. AU - Kellum, J. A. AU - Huang, D. T. AU - Barnato, A. E. AU - Weissfeld, L. A. AU - Pike, F. PY - 2014 DA - 2014// TI - A randomized trial of protocol-based care for early septic shock JO - N Engl J Med VL - 370 ID - Yealy2014 ER - TY - JOUR AU - Peake, S. L. AU - Delaney, A. AU - Bailey, M. AU - Bellomo, R. AU - Cameron, P. A. AU - Cooper, D. J. PY - 2014 DA - 2014// TI - Goal-directed resuscitation for patients with early septic shock JO - N Engl J Med VL - 371 ID - Peake2014 ER - TY - JOUR AU - Reade, M. C. AU - Huang, D. T. AU - Bell, D. AU - Coats, T. J. AU - Cross, A. M. AU - Peake, S. L. PY - 2008 DA - 2008// TI - Severe sepsis: international and specialty variations in initial management JO - Crit Care VL - 12 ID - Reade2008 ER - TY - JOUR AU - Mouncey, P. R. AU - Osborn, T. M. AU - Power, G. S. AU - Harrison, D. A. AU - Sadique, M. Z. AU - Grieve, R. D. PY - 2015 DA - 2015// TI - Trial of early, goal-directed resuscitation for septic shock JO - N Engl J Med VL - 372 ID - Mouncey2015 ER - TY - JOUR AU - Stevenson, E. K. AU - Rubenstein, A. R. AU - Radin, G. T. AU - Wiener, R. S. AU - Walkey, A. J. PY - 2014 DA - 2014// TI - Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis JO - Crit Care Med VL - 42 ID - Stevenson2014 ER - TY - JOUR AU - Russell, J. A. AU - Walley, K. R. AU - Singer, J. AU - Gordon, A. C. AU - Hébert, P. C. AU - Cooper, D. J. PY - 2008 DA - 2008// TI - Vasopressin versus norepinephrine infusion in patients with septic shock JO - N Engl J Med VL - 358 ID - Russell2008 ER - TY - JOUR AU - Leone, M. AU - Asfar, P. AU - Radermacher, P. AU - Vincent, J. L. AU - Martin, C. PY - 2015 DA - 2015// TI - Optimizing mean arterial pressure in septic shock: a critical reappraisal of the literature JO - Crit Care VL - 19 ID - Leone2015 ER - TY - JOUR AU - Ledoux, D. AU - Astiz, M. E. AU - Carpati, C. M. AU - Rackow, E. C. PY - 2000 DA - 2000// TI - Effects of perfusion pressure on tissue perfusion in septic shock JO - Crit Care Med VL - 28 ID - Ledoux2000 ER - TY - JOUR AU - Bourgoin, A. AU - Leone, M. AU - Delmas, A. AU - Garnier, F. AU - Albanese, J. AU - Martin, C. PY - 2005 DA - 2005// TI - Increasing mean arterial pressure in patients with septic shock: effects of oxygen variables and renal function JO - Crit Care Med VL - 33 ID - Bourgoin2005 ER - TY - JOUR AU - Jhanji, S. AU - Stirling, S. AU - Patel, N. AU - Hinds, C. J. AU - Pearse, R. M. PY - 2009 DA - 2009// TI - The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock JO - Crit Care Med VL - 37 ID - Jhanji2009 ER - TY - JOUR AU - Thooft, A. AU - Favory, R. AU - Salgado, D. R. AU - Taccone, F. S. AU - Donadello, K. AU - Backer, D. PY - 2011 DA - 2011// TI - Effects of changes in arterial pressure on organ perfusion during septic shock JO - Crit Care VL - 15 ID - Thooft2011 ER - TY - JOUR AU - Badin, J. AU - Boulain, T. AU - Ehrmann, S. AU - Skarzynski, M. AU - Bretagnol, A. AU - Buret, J. PY - 2011 DA - 2011// TI - Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study JO - Crit Care VL - 15 ID - Badin2011 ER - TY - JOUR AU - Asfar, P. AU - Meziani, F. AU - Hamel, J. F. AU - Grelon, F. AU - Megarbane, B. AU - Anguel, N. PY - 2014 DA - 2014// TI - High versus low blood-pressure target in patients with septic shock JO - N Engl J Med VL - 370 ID - Asfar2014 ER - TY - JOUR AU - Waechter, J. AU - Kumar, A. AU - Lapinsky, S. E. AU - Marshall, J. AU - Dodek, P. AU - Arabi, Y. PY - 2014 DA - 2014// TI - Interaction between fluids and vasoactive agents on mortality in septic shock: a multicenter, observational study JO - Crit Care Med VL - 42 ID - Waechter2014 ER - TY - JOUR AU - Bai, X. AU - Yu, W. AU - Ji, W. AU - Lin, Z. AU - Tan, S. AU - Duan, K. PY - 2014 DA - 2014// TI - Early versus delayed administration of norepinephrine in patients with septic shock JO - Crit Care VL - 18 ID - Bai2014 ER - TY - JOUR AU - Beck, V. AU - Chateau, D. AU - Bryson, G. L. AU - Pisipati, A. AU - Zanotti, S. AU - Parrillo, J. E. PY - 2014 DA - 2014// TI - Timing of vasopressor initiation and mortality in septic shock: a cohort study JO - Crit Care VL - 18 ID - Beck2014 ER - TY - JOUR AU - Hébert, P. C. AU - Wells, G. AU - Blajchman, M. A. AU - Marshall, J. AU - Martin, C. AU - Pagliarello, G. PY - 1999 DA - 1999// TI - A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group JO - N Engl J Med VL - 340 ID - Hébert1999 ER - TY - JOUR AU - Holst, L. B. AU - Haase, N. AU - Wetterslev, J. AU - Wernerman, J. AU - Guttormsen, A. B. AU - Karlsson, S. PY - 2014 DA - 2014// TI - Lower versus higher hemoglobin threshold for transfusion in septic shock JO - N Engl J Med VL - 371 ID - Holst2014 ER - TY - JOUR AU - Monnet, X. AU - Teboul, J. -. L. PY - 2007 DA - 2007// TI - Volume responsiveness JO - Curr Opin Crit Care VL - 13 ID - Monnet2007 ER - TY - JOUR AU - Marik, P. E. AU - Monnet, X. AU - Teboul, J. -. L. PY - 2011 DA - 2011// TI - Hemodynamic parameters to guide fluid therapy JO - Annals of Intensive Care VL - 1 ID - Marik2011 ER - TY - JOUR AU - Kalantari, K. AU - Chang, J. N. AU - Ronco, C. AU - Rosner, M. H. PY - 2013 DA - 2013// TI - Assessment of intravascular volume status and volume responsiveness in critically ill patients JO - Kidney Int VL - 83 ID - Kalantari2013 ER - TY - JOUR AU - Walley, K. R. PY - 2011 DA - 2011// TI - Use of central venous oxygen saturation to guide therapy JO - Am J Respir Crit Care Med VL - 184 ID - Walley2011 ER - TY - JOUR AU - Monnet, X. AU - Teboul, J. -. L. PY - 2013 DA - 2013// TI - Assessment of volume responsiveness during mechanical ventilation: recent advances JO - Crit Care VL - 17 ID - Monnet2013 ER - TY - JOUR AU - Marik, P. E. AU - Cavallazzi, R. AU - Vasu, T. AU - Hirani, A. PY - 2009 DA - 2009// TI - Dynamic changes in arterial waveform derived variables and fluid responsiveness in mechanically ventilated patients: a systematic review of the literature JO - Crit Care Med VL - 37 ID - Marik2009 ER - TY - JOUR AU - Nagdev, A. D. AU - Merchant, R. C. AU - Tirado-Gonzalez, A. AU - Sisson, C. A. AU - Murphy, M. C. PY - 2010 DA - 2010// TI - Emergency department bedside ultrasonographic measurement of the caval index for noninvasive determination of low central venous pressure JO - Ann Emerg Med VL - 55 ID - Nagdev2010 ER - TY - JOUR AU - Muller, L. AU - Toumi, M. AU - Bousquet, P. J. AU - Riu-Poulenc, B. AU - Louart, G. AU - Candela, D. PY - 2011 DA - 2011// TI - An increase in aortic blood flow after an infusion of 100 ml colloid over 1 minute can predict fluid responsiveness: the mini-fluid challenge study JO - Anesthesiology VL - 115 ID - Muller2011 ER - TY - JOUR AU - Duus, N. AU - Shogilev, D. J. AU - Skibsted, S. AU - Zijlstra, H. W. AU - Fish, E. AU - Oren-Grinberg, A. PY - 2015 DA - 2015// TI - The reliability and validity of passive leg raise and fluid bolus to assess fluid responsiveness in spontaneously breathing emergency department patients JO - J Crit Care VL - 30 ID - Duus2015 ER - TY - JOUR AU - Davies, S. J. AU - Davenport, A. PY - 2014 DA - 2014// TI - The role of bioimpedance and biomarkers in helping to aid clinical decision-making of volume assessments in dialysis patients JO - Kidney Int VL - 86 ID - Davies2014 ER - TY - JOUR AU - Jansen, T. C. AU - Bommel, J. AU - Schoonderbeek, F. J. AU - Sleeswijk Visser, S. J. AU - Klooster, J. M. AU - Lima, A. P. PY - 2010 DA - 2010// TI - Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label randomized controlled trial JO - Am J Respir Crit Care Med VL - 182 ID - Jansen2010 ER - TY - JOUR AU - Jones, A. E. AU - Shapiro, N. I. AU - Trzeciak, S. AU - Arnold, R. C. AU - Claremont, H. A. AU - Kline, J. A. PY - 2010 DA - 2010// TI - Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial JO - JAMA VL - 303 ID - Jones2010 ER - TY - JOUR AU - Ait-Oufella, H. AU - Bourcier, S. AU - Alves, M. AU - Galbois, A. AU - Baudel, J. L. AU - Margetis, D. PY - 2013 DA - 2013// TI - Alteration of skin perfusion in mottling area during septic shock JO - Ann Intensive Care VL - 3 ID - Ait-Oufella2013 ER - TY - JOUR AU - Sakr, Y. AU - Dubois, M. J. AU - Backer, D. AU - Creteur, J. AU - Vincent, J. L. PY - 2004 DA - 2004// TI - Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock JO - Crit Care Med VL - 32 ID - Sakr2004 ER - TY - JOUR AU - Vincent, J. L. AU - Opal, S. M. AU - Marshall, J. C. PY - 2010 DA - 2010// TI - Ten reasons why we should not use severity scores as entry criteria for clinical trials or in our treatment decisions JO - Crit Care Med VL - 38 ID - Vincent2010 ER - TY - JOUR AU - Pierrakos, C. AU - Vincet, J. L. PY - 2010 DA - 2010// TI - Sepsis biomarkers: a review JO - Crit Care VL - 14 ID - Pierrakos2010 ER - TY - JOUR AU - Maslove, D. M. AU - Tang, B. M. AU - McLean, A. S. PY - 2012 DA - 2012// TI - Identification of sepsis subtypes in critically ill adults using gene expression profiling JO - Crit Care VL - 16 ID - Maslove2012 ER - TY - JOUR AU - Kairalla, J. A. AU - Coffey, C. S. AU - Thomann, M. A. AU - Muller, K. E. PY - 2012 DA - 2012// TI - Adaptive trial designs: a review of barriers and opportunities JO - Trials VL - 13 ID - Kairalla2012 ER - TY - JOUR AU - Berry, D. A. PY - 2011 DA - 2011// TI - Adaptive clinical trials in oncology JO - Nat Rev Clin Oncol VL - 9 ID - Berry2011 ER -