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Table 2 Univariate analysis for predictors of prolonged ventilation and PICU length of stay, and for drop in PELOD score between days 1 to 3 of sepsis

From: Timing of antibiotics, volume, and vasoactive infusions in children with sepsis admitted to intensive care

Variable

Ventilated 1–7 d

Ventilated >7 d

P value

PICU 0–7 d

PICU >7 d

P value

Δ PELOD ≤ median

Δ PELOD > median

P value

Number

45

19

 

33

46

 

40

35

 

Age, months

82 (62)

62 (66)

0.17

90 (64)

67 (63)

0.12

60 (65)

94 (59)

0.022

PRISM

10.4 (6.1)

14.5 (8.6)

0.02

10.3 (5.5)

13.0 (8.3)

0.11

11.5 (6.6)

12.7 (7.5)

0.45

PELOD

14.4 (8)

20.7 (11)

0.007

14.4 (8.6)

17.8 (10.4)

0.13

-

-

 

Severe underlying disease

18/45 (40 %)

19/29 (66 %)

0.056

11/33 (33 %)

28/46 (61 %)

0.022

22/40 (55 %)

14/35 (40 %)

0.25

Delta PELOD

6.9 (8.4)

2.7 (14.0)

0.12

8.1 (8.4)

3.4 (11.9)

0.06

-

-

 

Time to Abx

243 (306)

235 (359)

0.92

223 (296)

243 (336)

0.79

234 (329)

239 (325)

0.95

Abx in first hour

10/45 (22 %)

9/29 (31 %)

0.43

5/33 (15 %)

15/46 (33 %)

0.12

13/40 (33 %)

7/35 (20 %)

0.30

Time to inotropes

546 (395)

428 (342)

0.32

654 (368)

428 (359)

0.056

533 (421)

493 (344)

0.74

Inotropes within 3 h

6/24 (25 %)

5/18 (28 %)

0.66

2/15 (13 %)

9/29 (31 %)

0.27

6/20 (30 %)

4/22 (18 %)

0.34

Time to 20 ml/kg volume

225 (247)

132 (179)

0.22

212 (220)

185 (252)

0.75

233 (306)

152 (167)

0.32

Volume in 2 h

20.2 (17.6)

36.7 (34.9)

0.05

23 (18.9)

29 (30.2)

0.48

23 (23)

33 (30)

0.27

Volume ≤20 ml/kg in 2 h

16/24 (67 %)

9/18 (50 %)

0.35

10/15 (67 %)

16/29 (55 %)

0.53

14/20 (70 %)

10/22 (45 %)

0.098

Volume to inotropes

35.2 (32.1)

46.7 (34.4)

0.27

41 (35)

39 (32)

0.88

37 (28)

46 (36)

0.35

Ventilator days

-

-

 

-

-

 

10.3 (11.2)

5.8 (5.1)

0.036

PICU days

-

-

 

-

-

 

15.8 (17.8)

9.7 (8.1)

0.071

  1. Comparisons were performed using the t test for independent samples, and Fisher’s exact test as appropriate. Values are given as mean (standard deviation) or proportion (percent); times are given in minutes. PICU pediatric ICU, PELOD pediatric logistic organ dysfunction score, Abx antibiotic therapy