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Table 3 Mortality at 30 days and 365 days following admission in 57,110 adult ICU patients with and without atrial fibrillation

From: Pre-existing atrial fibrillation and risk of arterial thromboembolism and death in intensive care unit patients: a population-based cohort study

 

AF, %

No AF, %

Crude RRa

Adjusted RRa,b

30-day mortality

    

Overall

26.8 (25.6–28.0)

16.0 (15.7–16.4)

1.67 (1.59–1.76)

1.04 (0.99–1.10)

Age

    

  15–54 yr

13.6 (10.0–18.5)

6.1 (5.7–6.4)

2.25 (1.64–3.08)

1.73 (1.29–2.32)

  55–70 yr

16.7 (14.9–18.7)

14.6 (14.1–15.1)

1.14 (1.02–1.29)

1.09 (0.96–1.24)

  71–105 yr

32.6 (31.0–34.2)

28.5 (27.8–29.2)

1.14 (1.08–1.21)

1.04 (0.98–1.10)

Sex

    

  Female

30.0 (28.0–32.1)

16.7 (16.2–17.2)

1.80 (1.67–1.93)

1.05 (0.97–1.14)

  Male

24.9 (23.4–26.4)

15.5 (15.1–16.0)

1.60 (1.50–1.71)

1.04 (0.97–1.12)

Prior myocardial infarction

    

  Not present

26.2 (24.9–27.6)

15.6 (15.3–16.0)

1.68 (1.59–1.77)

1.04 (0.98–1.11)

  Present

29.1 (26.4–31.9)

20.0 (18.9–21.1)

1.46 (1.31–1.63)

1.06 (0.93–1.19)

Congestive heart failure

    

  Not present

24.2 (22.8–25.7)

15.3 (15.0–15.6)

1.58 (1.49–1.69)

1.04 (0.97–1.10)

  Present

31.9 (29.7–34.1)

27.7 (26.2–29.3)

1.15 (1.05–1.26)

1.08 (0.99–1.18)

Mechanical ventilation

    

  No

24.9 (24.3–25.5)

11.2 (10.9–11.5)

2.10 (1.96–2.26)

1.00 (0.93–1.08)

  Yes

31.3 (29.4–33.3)

23.6 (22.1–25.1)

1.26 (1.18–1.35)

1.12 (1.05–1.20)

Renal replacement therapy

    

  No

25.9 (24.7–27.1)

15.3 (15.0–15.6)

1.69 (1.60–1.78)

1.04 (0.98–1.09)

  Yes

44.1 (38.2–50.4)

41.7 (39.2–44.3)

1.06 (0.91–1.23)

1.04 (0.88–1.22)

Treatment with inotropes or vasopressors

    

  No

24.3 (22.8–25.9)

12.1 (11.7–12.4)

2.02 (1.88–2.16)

1.02 (0.94–1.09)

  Yes

30.4 (28.5–32.4)

25.9 (25.2–26.6)

1.17 (1.09–1.26)

1.08 (1.01–1.16)

Non-invasive ventilation

    

  No

25.2 (24.0–26.5)

14.7 (14.4–15.0)

1.72 (1.63–1.81)

1.06 (1.00–1.12)

  Yes

39.6 (35.7–43.9)

33.3 (31.8–34.8)

1.19 (1.06–1.33)

0.98 (0.88–1.10)

Surgery performed, any type

    

  No

36.0 (33.9–38.1)

21.2 (20.6–21.7)

1.70 (1.59–1.81)

0.99 (0.93–1.06)

  Yes

20.7 (19.3–22.2)

12.9 (12.5–13.3)

1.60 (1.49–1.73)

1.03 (0.95–1.12)

Cardiac surgery performed

    

  No

31.9 (30.5–33.3)

17.5 (17.1–17.8)

1.82 (1.74–1.92)

1.02 (0.97–1.08)

  Yes

7.1 (5.7–8.9)

6.3 (5.7–6.9)

1.13 (0.89–1.44)

0.80 (0.52–1.23)

Abdominal surgery performed

    

  No

26.2 (24.9–27.6)

15.8 (15.5–16.2)

1.65 (1.56–1.75)

1.05 (0.99–1.11)

  Yes

29.6 (26.7 -32.7)

16.7 (16.2–17.7)

1.75 (1.56–1.95)

1.02 (0.91 -1.14)

Orthopaedic surgery performed

    

  No

26.5 (25.3–27.7)

16.1 (15.7–16.4)

1.65 (1.57–1.74)

1.05 (1.00–1.11)

  Yes

33.3 (27.7–39.7)

15.9 (14.6–17.4)

2.09 (1.71–2.56)

1.03 (0.80–1.31)

Vascular surgery performed

    

  No

27.2 (25.9–28.4)

16.4 (16.0–16.7)

1.66 (1.58–1.75)

1.04 (0.99–1.10)

  Yes

16.8 (12.0–23.1)

10.4 (9.3–11.6)

1.61 (1.14–2.28)

0.64 (0.31–1.33)

365-day mortality

    

Overall

40.9 (40.0–42.3)

25.4 (25.0–25.8)

1.61 (1.55–1.67)

1.03 (1.00–1.07)

Age

    

  15–55 yr

19.9 (15.5–25.3)

9.8 (9.4–10.3)

2.02 (1.57–2.59)

1.34 (1.06–1.69)

  55–71 yr

28.0 (25.8–30.3)

24.8 (24.2–25.5)

1.13 (1.04–1.23)

1.07 (0.98–1.16)

  71–105 yr

48.6 (46.9–50.4)

43.1 (42.4–43.9)

1.13 (1.08–1.17)

1.03 (1.00–1.07)

Sex

    

  Female

45.6 (43.4–48.9)

25.9 (25.4–26.5)

1.76 (1.67–1.86)

1.07 (1.01–1.13)

  Male

38.1 (36.4–39.8)

25.0 (24.5–25.5)

1.53 (1.45–1.60)

1.01 (0.96–1.05)

Prior myocardial infarction

    

  Not present

39.9 (38.4–41.5)

24.8 (24.4–25.2)

1.61 (1.55–1.68)

1.02 (0.98–1.07)

  Present

44.7 (41.8–47.8)

31.2 (29.9–32.5)

1.43 (1.33–1.55)

1.07 (0.99–1.16)

Congestive heart failure

    

  Not present

37.1 (35.5–38.8)

24.2 (23.8–24.6)

1.53 (1.46–1.61)

1.04 (0.99–1.08)

  Present

48.4 (46.0––50.7)

43.8 (42.1–45.6)

1.10 (1.04–1.18)

1.04 (0.98–1.10)

Mechanical ventilation

    

  No

38.8 (38.1–41.6)

21.1 (20.6–21.5)

1.89 (1.80–1.99)

1.00 (0.95–1.05)

  Yes

42.4 (40.4–44.6)

33.3 (32.6–34.0)

1.27 (1.21–1.34)

1.09 (1.04–1.15)

Renal replacement therapy

    

  No

39.6 (38.3–41.0)

24.4 (24.1–24.8)

1.62 (1.56–1.68)

1.03 (0.99–1.06)

  Yes

63.4 (59.5–71.2)

59.2 (56.6–61.7)

1.10 (1.00–1.22)

1.04 (0.94–1.15)

Treatment with inotropes or vasopressors

    

  No

46.6 (39.2–54.6)

28.7 (26.4–31.2)

1.62 (1.35–1.95)

1.00 (0.82–1.21)

  Yes

52.3 (45.1–60.0)

42.9 (40.3–45.6)

1.22 (1.04–1.43)

0.96 (0.82–1.12)

Non-invasive ventilation

    

  No

47.6 (41.6–54.0)

32.2 (30.3–34.3)

1.48 (1.28–1.71)

0.99 (0.85–1.15)

  Yes

55.3 (45.1–66.0)

48.6 (44.6–52.7)

1.14 (0.92–1.40)

0.96 (0.78–1.18)

Surgery performed, any type

    

  No

50.1 (47.9–52.3)

30.6 (30.0–31.3)

1.64 (1.56–1.72)

0.96 (0.92–1.01)

  Yes

34.8 (33.1–36.5)

22.2 (21.7–22.6)

1.57 (1.49–1.66)

1.07 (1.02–1.13)

Cardiac surgery performed

    

  No

47.6 (46.1–49.2)

27.6 (27.2–28.1)

1.72 (1.66–1.79)

1.00 (0.97–1.04)

  Yes

14.9 (12.9–17.3)

10.2 (9.5–10.9)

1.47 (1.25–1.73)

1.11 (0.88–1.40)

Abdominal surgery performed

    

  No

39.7 (38.3–41.2)

24.7 (24.3–25.1)

1.61 (1.55–1.68)

1.03 (0.99–1.07)

  Yes

46.4 (43.2–49.7)

28.6 (27.7–29.5)

1.62 (1.50–1.75)

1.04 (0.97–1.12)

Orthopaedic surgery performed

    

  No

40.3 (38.9–41.7)

25.5 (25.1–25.9)

1.58 (1.52–1.64)

1.03 (0.99–1.07)

  Yes

54.4 (48.2–60.9)

24.1 (22.5–25.8)

2.27 (1.98–2.59)

1.11 (0.97–1.27)

Vascular surgery performed

    

  No

41.2 (39.8–42.6)

25.8 (25.4–26.2)

1.60 (1.54–1.66)

1.02 (0.99–1.06)

  Yes

33.0 (26.6–40.4)

18.0 (16.6–19.5)

1.83 (1.47–2.29)

1.18 (0.88 -1.57)

  1. AF atrial fibrillation, RR relative risk
  2. 95 % confidence intervals are given in parentheses
  3. aReference group was non-AF patients within each stratum
  4. bAdjusted for age and sex, comorbidities, and consultations and services provided by the general practitioner