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Table 3 Excluded randomized studies of enteral glutamine supplementation in critically ill patients

From: Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis

Author Year Reasons for exclusion References
Jebb et al. 1995 Transplant and/or elective surgery patients [34]
Long et al. 1995 No clinical outcomes [35]
Jensen et al. 1996 No clinical outcomes [36]
Fish et al. 1997 Cancer patients [37]
Scolapio et al. 1997 Crossover design [38]
Anderson et al. 1998 Surgical patients [39]
Anderson et al. 1998 Pediatric cancer patients [40]
Den Hond et al. 1999 Not ICU patients [41]
Schloerb and Skikne 1999 Cancer and/or surgery patients [42]
Scolapio 1999 Crossover design [43]
Zhou et al. 1999 Earlier study of 2003 RCT already included [44]
Jackson et al. 2000 Surgery patients, no clinical outcomes [45]
Szkudlarek et al. 2000 Crossover design [46]
Chen et al. 2001 No clinical outcomes [47]
Scolapio et al. 2001 Crossover design [48]
Velasco et al. 2001 No clinical outcomes, duplicate of Houdijk et al. study [24] [49]
Boelens et al. 2002 No clinical outcomes [50]
Novak et al. 2002 Studies on critically ill patients were included in this review [51]
Flaring et al. 2003 Elective surgery patients [52]
García-de-Lorenzo et al. 2003 Systematic review, Individual studies were included in this review [53]
Boelens et al. 2004 Duplicate of Houdijk et al. study [24] [54]
Falcao de Arruda et al. 2004 Includes probiotics [55]
Peng et al. 2005 Duplicate study of earlier publication already [30] included [56]
Peng et al. 2006 Duplicate of a previous study [30] [57]
Guo et al. 2007 No clinical outcomes [58]
Kuhls et al. 2007 Too many interventions [59]
Spindler-Vesel et al. 2007 Too many interventions: RCT of GLN vs. fiber vs. peptide vs. fiber + synbiotics [60]
Beale et al. 2008 Non-isonitrogenous intervention including arginine and glycine [61]
Han et al. 2012 Elective surgery patients [62]
Cavalcante et al. 2012 No clinical outcomes, crossover design [63]
Han et al. 2014 No clinical outcomes [64]
Koksal et al. 2014 Only duration of mechanical ventilation reported [65]
  1. GLN glutamine, ICU intensive care unit, RCT randomized controlled trial