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Table 4 Multivariate analysis of risk factors for hospital mortality in patients with severe sepsis and septic shock

From: Adequate antibiotic therapy prior to ICU admission in patients with severe sepsis and septic shock reduces hospital mortality

  Severe sepsis Septic shock
  Adjusted OR (95% CI) p value Adjusted OR (95% CI) p value
Age 1.02 (1.00–1.05) 0.033   
APACHE II score 1.07 (1.01–1.14) 0.020 1.11 (1.07–1.15) <0.001
Cirrhosis    4.49 (1.55–13.04) 0.006
Immunosuppression 4.39 (1.64–11.72) 0.003   
Urinary sepsis source    0.11 (0.05–0.27) <0.001
Nosocomial infection 6.53 (2.74–15.55) <0.001   
Prior ICU adequate antimicrobial therapy 0.29 (0.13–0.63) 0.002 0.40 (0.24–0.65) <0.001
  1. APACHE Acute Physiology and Chronic Health Evaluation, CI confidence interval, OR odds ratio