Black-white racial disparities in sepsis: a prospective analysis of the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort

Table 2 Association between race and first-infection and first-sepsis events

	Black vs. white
	Events, number (%)	Incidence density per 1,000 person-years	Crude hazard ratio*	Model 1^a	Model 2^b	Model 3^c	Model 4^d
		(95 % CI)	(95 % CI)	(95 % CI)	(95 % CI)	(95 % CI)	(95 % CI)
First-infection event
White	1721 (5.8)	15.76 (15.65, 15.87)	0.77 (0.71, 0.84)	0.70 (0.64, 0.76)	0.68 (0.63, 0.75)	0.65 (0.59, 0.71)	0.65 (0.59, 0.71)
Black	879 (3.0)	12.10 (11.95, 12.26)	0.77 (0.71, 0.84)	0.70 (0.64, 0.76)	0.68 (0.63, 0.75)	0.65 (0.59, 0.71)	0.65 (0.59, 0.71)
First-sepsis event
White	1015 (3.4)	9.10 (8.96, 9.25)	0.76 (0.69, 0.85)	0.68 (0.61, 0.76)	0.67 (0.60, 0.75)	0.63 (0.56, 0.71)	0.64 (0.57, 0.72)
Black	511 (1.7)	6.93 (6.73, 7.13)	0.76 (0.69, 0.85)	0.68 (0.61, 0.76)	0.67 (0.60, 0.75)	0.63 (0.56, 0.71)	0.64 (0.57, 0.72)
	Events, number (%)	-	Crude odds ratio‡	Model 1^a	Model 2^b	Model 3^c	Model 4^d
	Events, number (%)	-	(95 % CI)	(95 % CI)	(95 % CI)	(95 % CI)	(95 % CI)
Sepsis (given first-infection event)
White	918 (53.4)	-	1.01 (0.86, 1.19)	0.99 (0.84, 1.18)	0.99 (0.83, 1.17)	1.00 (0.83, 1.19)	1.01 (0.84, 1.21)
Black	471 (53.5)	-	1.01 (0.86, 1.19)	0.99 (0.84, 1.18)	0.99 (0.83, 1.17)	1.00 (0.83, 1.19)	1.01 (0.84, 1.21)

^aAdjusted for sex, age, and geographic region, education level, and income. ^bAdjusted for model 1 covariates plus tobacco and alcohol use. ^cAdjusted for model 2 covariates plus baseline chronic medical conditions. ^dAdjusted for model 3 covariates plus biomarkers. *Estimated from Cox proportional hazard model. ^‡Estimated from logistic regression

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