Category | AEs and concomitant treatments | Total N (%) | CPC 1 and 2 n (%) | CPC 3–5 n (%) | OR (95 % CI) | p | Adjusted OR (95 % CI) | p |
---|---|---|---|---|---|---|---|---|
 |  | 704 (100) | 228(32.4) | 476 (67.6) |  |  |  |  |
Cooling -related AEs | Overcoolinga | 128 (18.2) | 23 (10.1) | 105 (22.1) | 2.52 (1.56–4.09) | <.001 | 1.16 (0.58–2.31) | 0.681 |
Bradycardiab | 83 (11.8) | 35 (15.4) | 48 (10.1) | 0.62 (0.39–0.99) | 0.044 | 0.75 (0.37–1.53) | 0.429 | |
Tachyarrhythmia | 67 (9.5) | 24 (10.5) | 43 (9.0) | 0.84 (0.50–1.43) | 0.528 | 0.72 (0.33–1.55) | 0.398 | |
Hypokalemiac | 220 (31.3) | 65 (28.5) | 155 (32.6) | 1.21 (0.86–1.71) | 0.278 | 1.21 (0.71–2.04) | 0.486 | |
Hyperglycemiad | 321 (45.6) | 81 (35.5) | 240 (50.4) | 1.85 (1.33–2.56) | <.001 | 1.37 (0.84–2.24) | 0.210 | |
Bleeding | 21 (3.0) | 6 (2.6) | 15 (3.2) | 1.20 (0.46–3.15) | 0.705 | 0.89 (0.21–3.71) | 0.872 | |
Hypotensione | 204 (29.0) | 54 (23.7) | 150 (31.5) | 1.48 (1.03–2.13) | 0.033 | 1.03 (0.59–1.79) | 0.926 | |
Rewarming -related AEs | Rebound hyperthermiaf | 85 (12.1) | 29 (12.7) | 56 (11.8) | 0.92 (0.57–1.48) | 0.716 | 1.33 (0.61–2.92) | 0.473 |
Arrhythmia | 42 (6.0) | 10 (4.4) | 32 (6.7) | 1.57 (0.76–3.25) | 0.224 | 1.70 (0.61–4.69) | 0.308 | |
Hyperkalemiag | 48 (6.8) | 7 (3.1) | 41 (8.6) | 2.96 (1.31–6.74) | 0.009 | 1.09 (0.37–3.19) | 0.881 | |
Hypoglycemiah | 70 (9.9) | 22 (9.7) | 48 (10.7) | 1.05 (0.62–1.79) | 0.858 | 1.14 (0.50–2.57) | 0.762 | |
Bleeding | 14 (2.0) | 3 (1.3) | 11 (2.3) | 1.77 (0.49–6.41) | 0.383 | 1.05 (0.18–6.06) | 0.956 | |
Hypotensione | 152 (21.6) | 36 (15.8) | 116 (24.4) | 1.72 (1.14–2.60) | 0.01 | 0.99 (0.54–1.83) | 0.984 | |
Other AEs during advanced critical care Concomitant treatments | Pneumoniai | 279 (39.6) | 70 (30.7) | 209 (43.9) | 1.77 (1.26–2.47) | <.001 | 1.05 (0.63–1.74) | 0.852 |
Sepsis | 100 (14.2) | 17 (7.5) | 83 (17.4) | 2.62 (1.52–4.53) | <.001 | 3.12 (1.40–6.97) | 0.005 | |
Myoclonusj | 154 (21.9) | 34 (14.9) | 120 (25.2) | 1.92 (1.27–2.92) | 0.002 | 3.72 (1.93–7.16) | <.001 | |
Seizurek | 153 (21.7) | 24 (10.5) | 129 (27.1) | 3.16 (1.98–5.05) | <.001 | 4.02 (2.04–7.91) | <.001 | |
Hypoglycemial | 162 (23.0) | 36 (15.8) | 126 (26.5) | 1.92 (1.27–2.89) | 0.002 | 2.03 (1.09–3.78) | 0.025 | |
Anticonvulsants | 287 (40.8) | 71 (31.1) | 216 (45.4) | 1.84 (1.32–2.56) | <.001 | 1.69 (1.03–2.77) | 0.039 | |
Insulin | 460 (65.3) | 136(59.7) | 324 (68.1) | 1.44 (1.04–2.00) | 0.028 | 0.98 (0.60–1.62) | 0.944 | |
Analgesics | 323 (45.9) | 122 (53.5) | 201 (42.2) | 0.64 (0.46–0.87) | 0.005 | 0.75 (0.46–1.21) | 0.239 | |
Sedatives | 657 (93.3) | 222 (97.4) | 435 (91.4) | 0.29 (0.12–0.69) | 0.005 | 0.92 (0.29–2.96) | 0.888 | |
Neuromuscular blockers | 475 (67.5) | 174 (76.3) | 301 (63.2) | 0.53 (0.37–0.76) | 0.001 | 0.48 (0.28–0.84) | 0.009 |