|
Characteristic
|
Ubiquinol (n = 19)
|
Placebo (n = 19)
|
|---|
|
Demographics
| | |
|
Age (years)
|
60 ± 18
|
64 ± 14
|
|
Sex (female)
|
11 (58 %)
|
7 (37 %)
|
|
Race (white)
|
14 (78 %)
|
15 (83 %)
|
|
Co-morbidities
| | |
|
Coronary artery disease
|
2 (11 %)
|
2 (11 %)
|
|
Congestive heart failure
|
2 (11 %)
|
2 (11 %)
|
|
Hyperlipidemia
|
6 (32 %)
|
2 (11 %)
|
|
Hypertension
|
12 (63 %)
|
9 (47 %)
|
|
Chronic obstructive pulmonary disease
|
2 (11 %)
|
3 (16 %)
|
|
Diabetes
|
6 (32 %)
|
8 (42 %)
|
|
Liver disease
|
1 (6 %)
|
0 (0)
|
|
Renal disease
|
3 (16 %)
|
1 (6 %)
|
|
Cancer
|
4 (21 %)
|
9 (47 %)
|
|
Vital signs at enrollment
| | |
|
Heart rate
|
92 ± 19
|
88 ± 22
|
|
Systolic blood pressure
|
109 ± 19
|
105 ± 11
|
|
Diastolic blood pressure
|
54 ± 16
|
61 ± 11
|
|
Respiratory rate
|
25 ± 6
|
22 ± 6
|
|
Temperature
|
98.4 ± 1.4
|
98.7 ± 1.1
|
|
Laboratory values at enrollment
| | |
|
Lactate (mmol/L)
|
1.6 (1.1-2.5)
|
1.3 (1.0-1.6)
|
|
Creatinine (mg/dL)
|
1.7 (1.0-3.0)
|
1.0 (0.7-1.7)
|
|
Bicarbonate (mEq/L)
|
30 ± 7
|
34 ± 7
|
|
White blood count (K/μL)
|
13.2 ± 6.3
|
16.5 ± 11.4
|
|
Hematocrit (%)
|
30.0 ± 7.0
|
33.7 ± 7.4
|
|
Source of sepsis
| | |
|
Pneumonia
|
9 (47)
|
7 (37)
|
|
Urinary tract
|
2 (11)
|
2 (11)
|
|
Intraabdominal
|
1 (5)
|
3 (16)
|
|
Skin, joint, or soft tissue
|
2 (11)
|
4 (21)
|
|
Endocarditis
|
1 (5)
|
0 (0)
|
|
Unclear
|
4 (21)
|
3 (16)
|
|
Positive blood culture
|
5 (26)
|
6 (32)
|
|
Mechanical Ventilation
|
11 (58 %)
|
7 (37 %)
|
|
Vasopressors
|
12 (63 %)
|
12 (63 %)
|
|
APACHE II score at enrollment
|
19 ± 9
|
18 ± 10
|
|
Baseline CoQ10 Levels
| | |
|
Total CoQ10 (mcg/mL)
|
0.37 (0.30-0.62)
|
0.33 (0.25-0.69)
|
|
CoQ10 Reduced (mcg/mL)
|
0.31 (0.20-0.40)
|
0.30 (0.22-0.66)
|
|
CoQ10 Oxidized (mcg/mL)
|
0.05 (0.02-0.15)
|
0.03 (0.02-0.04)
|
|
CoQ10 %Reduced
|
0.87 (0.73-0.94)
|
0.92 (0.90-0.95)
|
|
CoQ10: Cholesterol
|
0.38 (0.28-0.65)
|
0.36 (0.26-0.55)
|
-
aBaseline values with continuous values expressed as means ± standard deviation or median (quartiles), depending on normality of the data. Categorical values are counts with frequencies. No comparisons had a P value <0.05
