Table 1 Selected baseline characteristicsa
Characteristic | Ubiquinol (n = 19) | Placebo (n = 19) |
|---|---|---|
Demographics | ||
Age (years) | 60 ± 18 | 64 ± 14 |
Sex (female) | 11 (58 %) | 7 (37 %) |
Race (white) | 14 (78 %) | 15 (83 %) |
Co-morbidities | ||
Coronary artery disease | 2 (11 %) | 2 (11 %) |
Congestive heart failure | 2 (11 %) | 2 (11 %) |
Hyperlipidemia | 6 (32 %) | 2 (11 %) |
Hypertension | 12 (63 %) | 9 (47 %) |
Chronic obstructive pulmonary disease | 2 (11 %) | 3 (16 %) |
Diabetes | 6 (32 %) | 8 (42 %) |
Liver disease | 1 (6 %) | 0 (0) |
Renal disease | 3 (16 %) | 1 (6 %) |
Cancer | 4 (21 %) | 9 (47 %) |
Vital signs at enrollment | ||
Heart rate | 92 ± 19 | 88 ± 22 |
Systolic blood pressure | 109 ± 19 | 105 ± 11 |
Diastolic blood pressure | 54 ± 16 | 61 ± 11 |
Respiratory rate | 25 ± 6 | 22 ± 6 |
Temperature | 98.4 ± 1.4 | 98.7 ± 1.1 |
Laboratory values at enrollment | ||
Lactate (mmol/L) | 1.6 (1.1-2.5) | 1.3 (1.0-1.6) |
Creatinine (mg/dL) | 1.7 (1.0-3.0) | 1.0 (0.7-1.7) |
Bicarbonate (mEq/L) | 30 ± 7 | 34 ± 7 |
White blood count (K/μL) | 13.2 ± 6.3 | 16.5 ± 11.4 |
Hematocrit (%) | 30.0 ± 7.0 | 33.7 ± 7.4 |
Source of sepsis | ||
Pneumonia | 9 (47) | 7 (37) |
Urinary tract | 2 (11) | 2 (11) |
Intraabdominal | 1 (5) | 3 (16) |
Skin, joint, or soft tissue | 2 (11) | 4 (21) |
Endocarditis | 1 (5) | 0 (0) |
Unclear | 4 (21) | 3 (16) |
Positive blood culture | 5 (26) | 6 (32) |
Mechanical Ventilation | 11 (58 %) | 7 (37 %) |
Vasopressors | 12 (63 %) | 12 (63 %) |
APACHE II score at enrollment | 19 ± 9 | 18 ± 10 |
Baseline CoQ10 Levels | ||
Total CoQ10 (mcg/mL) | 0.37 (0.30-0.62) | 0.33 (0.25-0.69) |
CoQ10 Reduced (mcg/mL) | 0.31 (0.20-0.40) | 0.30 (0.22-0.66) |
CoQ10 Oxidized (mcg/mL) | 0.05 (0.02-0.15) | 0.03 (0.02-0.04) |
CoQ10 %Reduced | 0.87 (0.73-0.94) | 0.92 (0.90-0.95) |
CoQ10: Cholesterol | 0.38 (0.28-0.65) | 0.36 (0.26-0.55) |