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Table 1 Selected baseline characteristicsa

From: Ubiquinol (reduced Coenzyme Q10) in patients with severe sepsis or septic shock: a randomized, double-blind, placebo-controlled, pilot trial

Characteristic Ubiquinol (n = 19) Placebo (n = 19)
Demographics   
 Age (years) 60 ± 18 64 ± 14
 Sex (female) 11 (58 %) 7 (37 %)
 Race (white) 14 (78 %) 15 (83 %)
Co-morbidities   
 Coronary artery disease 2 (11 %) 2 (11 %)
 Congestive heart failure 2 (11 %) 2 (11 %)
 Hyperlipidemia 6 (32 %) 2 (11 %)
 Hypertension 12 (63 %) 9 (47 %)
 Chronic obstructive pulmonary disease 2 (11 %) 3 (16 %)
 Diabetes 6 (32 %) 8 (42 %)
 Liver disease 1 (6 %) 0 (0)
 Renal disease 3 (16 %) 1 (6 %)
 Cancer 4 (21 %) 9 (47 %)
Vital signs at enrollment   
 Heart rate 92 ± 19 88 ± 22
 Systolic blood pressure 109 ± 19 105 ± 11
 Diastolic blood pressure 54 ± 16 61 ± 11
 Respiratory rate 25 ± 6 22 ± 6
 Temperature 98.4 ± 1.4 98.7 ± 1.1
Laboratory values at enrollment   
 Lactate (mmol/L) 1.6 (1.1-2.5) 1.3 (1.0-1.6)
 Creatinine (mg/dL) 1.7 (1.0-3.0) 1.0 (0.7-1.7)
 Bicarbonate (mEq/L) 30 ± 7 34 ± 7
 White blood count (K/μL) 13.2 ± 6.3 16.5 ± 11.4
 Hematocrit (%) 30.0 ± 7.0 33.7 ± 7.4
Source of sepsis   
 Pneumonia 9 (47) 7 (37)
 Urinary tract 2 (11) 2 (11)
 Intraabdominal 1 (5) 3 (16)
 Skin, joint, or soft tissue 2 (11) 4 (21)
 Endocarditis 1 (5) 0 (0)
 Unclear 4 (21) 3 (16)
Positive blood culture 5 (26) 6 (32)
Mechanical Ventilation 11 (58 %) 7 (37 %)
Vasopressors 12 (63 %) 12 (63 %)
APACHE II score at enrollment 19 ± 9 18 ± 10
Baseline CoQ10 Levels   
 Total CoQ10 (mcg/mL) 0.37 (0.30-0.62) 0.33 (0.25-0.69)
 CoQ10 Reduced (mcg/mL) 0.31 (0.20-0.40) 0.30 (0.22-0.66)
 CoQ10 Oxidized (mcg/mL) 0.05 (0.02-0.15) 0.03 (0.02-0.04)
 CoQ10 %Reduced 0.87 (0.73-0.94) 0.92 (0.90-0.95)
 CoQ10: Cholesterol 0.38 (0.28-0.65) 0.36 (0.26-0.55)
  1. aBaseline values with continuous values expressed as means ± standard deviation or median (quartiles), depending on normality of the data. Categorical values are counts with frequencies. No comparisons had a P value <0.05