Persistently elevated osteopontin serum levels predict mortality in critically ill patients

Roderburg, Christoph; Benz, Fabian; Cardenas, David Vargas; Lutz, Matthias; Hippe, Hans-Joerg; Luedde, Tom; Trautwein, Christian; Frey, Norbert; Koch, Alexander; Tacke, Frank; Luedde, Mark

doi:10.1186/s13054-015-0988-4

Critical Care

Table 3 Correlations of osteopontin serum concentrations with other laboratory markers

From: Persistently elevated osteopontin serum levels predict mortality in critically ill patients

	Osteopontin at admission vs. laboratory markers at admission day		Osteopontin at day 3 vs. laboratory markers at admission day		Osteopontin at day 3 vs. laboratory markers at day 3
	r	p	r	p	r	p
Markers of inflammation
CRP	0.306	0.001	0.202	0.033	0.050	0.601
Procalcitonin	0.378	0.006	0.295	0.010	0.620	<0.001
IL-10	−0.066	0.761	0.300	0.040	NA
IL-6	−0.131	0.629	0.081	0.612	0.153	0.464
Markers of organ function
Creatinine	0.258	0.006	0.307	0.001	0.363	<0.001
Cystatin	0.248	0.266	0.286	0.036	0.389	0.019
GFR	−0.235	0.047	−0.350	0.002	−0.390	0.001
AST	0.116	0.268	0.318	0.001	0.275	0.009
ALT	0.042	0.662	0.307	0.001	0.226	0.017
GLDH	−0.031	0.773	0.247	0.018	0.342	0.003
Bilirubin total	0.120	0.210	0.210	0.027	0.279	0.003
GGT	0.140	0.144	0.301	0.001	0.284	0.003
PCHE	−0.294	0.005	−0.159	0.126	−0.149	0.185
Albumin	−0.326	0.019	−0 206	0.090	−0.358	0.002
Urea	0.315	0.001	0.317	0.001	0.272	0.004
Iono lactate	0.040	0.696	0.349	<0.001	0.385	<0.001
LDH	0.210	0.027	0.379	<0.001	0.333	<0.001
BNP	0.224	0.045	NA		NA
Fibrinogen	0.323	0.191	−0.269	0.057	−0.461	0.005
Clinical scoring
APACHE II	0.292	0.012	0.230	0.036	0.294	0.062
SAPS2	0.800	0.104	0.387	0.008	0.312	0.031
SOFA	0.387	0.003	0.486	0.003	0.512	0.002
Experimental sepsis markers
APRIL	0.258	0.040	0.325	0.005	NA
miR-133	0.293	0.024	0.404	0.001	NA
NTproCNP	0.284	0.003	0.325	0.001	0.395	<0.001
suPAR	0.331	0.001	0.396	<0.001	0.393	<0.001
Leptin	−0.343	0.101	−0.015	0.918	NA
Leptin receptor	−0.249	0.241	0.260	0.075	NA
Adiponectin	0.083	0.700	0.305	0.035	NA
Ghrelin	0.058	0.786	−0.109	0.460	NA
Resistin	0.205	0.336	0.226	0.122	NA
Other
C-peptide	0.557	0.009	0.107	0.439	0.316	0.061
Iono BZ	−0.181	0.078	0.200	0.045	0.139	0.166
Survival time	−0.002	0.989	−0.342	0.017	−0.342	0.017
Protein	−0.350	0.003	−0.344	0.001	−0.278	0.059
Ventilation time total	0.151	0.141	0.212	0.032	0.212	0.032

NA not assessed, ALT alanine aminotransferase, APACHE Acute Physiology and Chronic Health Evaluation, APRIL, a proliferation-inducing ligand, AST aspartate aminotransferase, BNP brain natriuretic peptide, CRP C-reactive protein, GFR glomerular filtration rate, GGT gamma-glutamyl transpeptidase, GLDH glutamate dehydrogenase, IL interleukin, LDH lactate dehydrogenase, PCHE pseudocholinesterase, PCT procalcitonin, SAPS Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, SuPAR soluble urokinase-type plasminogen activator receptor

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ISSN: 1364-8535

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