Fig. 5

Prediction of long-term mortality by osteopontin serum concentrations. a and b High serum OPN serum levels indicate an impaired outcome in critically ill patients as patients that survived ICU treatment had lower OPN serum levels after 3 days of ICU treatment (p = 0.035, U test). Box plot are displayed, where the bold line indicates the median per group, the box represents 50 % of the values, and horizontal lines show minimum and maximum values of the calculated non-outlier values. c ROC curve analyses comparing the prognostic value of OPN levels at day 3 of ICU treatment for overall survival (AUC 0.752) with that of the initial SAPS2 – score (AUC 0.647) and day 3 SAPS2 – score (AUC 0.768). d ROC curve analyses comparing the prognostic value of OPN levels at day 3 of ICU treatment for overall survival (AUC 0.626) with that of WBC (AUC 0.475), CRP (AUC 0.446), bilirubin (AUC 0.560), INR (AUC 0.621) and creatinine (AUC 0.611). e Kaplan-Meier survival curves of ICU patients showed that patients with high OPN concentrations had an increased overall mortality compared to other patients. p values for log rank test are given in the figure. ^* p <0.05. AUC area under the curve, CRP C-reactive protein, ICU intensive care unit, INR international normalized ratio, OPN osteopontin, ROC receiver operating characteristic, SAPS Simplified Acute Physiology Score, WBC white blood cell count