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Fig. 2 | Critical Care

Fig. 2

From: Persistently elevated osteopontin serum levels predict mortality in critically ill patients

Fig. 2

Serum osteopontin concentrations of critically ill patients after 3 days of ICU treatment. a Serum OPN concentrations after 3 days of ICU treatment were analysed by ELISA. In the total patient cohort, OPN levels were significantly lower when compared to the values at admission to the ICU (p <0.001, U test). b Serum OPN levels after 3 days of ICU treatment were not further elevated in patients with a more severe diseases according to the initial Acute Physiology and Chronic Health Evaluation (APACHE) II scores (>10) compared to patients with low APACHE II scores (≤10). c Serum OPN concentrations at day 3 of ICU treatment are independent on the presence of type 2 diabetes. d Serum OPN concentrations at day 3 of ICU treatment are independent on the presence of obesity. e Patients that fulfilled sepsis criteria displayed no further increases in OPN serum levels at day 3 of ICU treatment compared to patients with non-septic disease. f OPN serum concentrations did not differ with regard to the disease aetiology in critically ill patients. pulmo, pulmonal; abd, abdominal; uro, urological; cirrh, cirrhosis; c.p., cardiopulmonary. Box plot are displayed, where the bold line indicates the median per group, the box represents 50 % of the values, and horizontal lines show minimum and maximum values of the calculated non-outlier values; asterisks and open circles indicate outlier values. N values are given in the figures and tables. *** p <0.001. ELISA enzyme-linked immunosorbent assay, ICU intensive care unit, OPN osteopontin

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