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Fig. 2 | Critical Care

Fig. 2

From: One-year survival and resource use after critical illness: impact of organ failure and residual organ dysfunction in a cohort study in Brazil

Fig. 2

Non-linear effect (a) and time-varying effect of age (b) on the log of the hazard ratio (HR) for 1-year survival following Intensive Care Unit discharge from the multivariate flexible Cox model. Panel (a) shows the log HR for age values, modeled through spline terms with 50 years old as the reference category (mean value). Panel (b) shows the time-varying effect of age reestimated within time intervals over 1 year. In (a), the solid red line denotes the estimated log HR and the gray region denotes the 95 % confidence interval. The black dashed line with arrow denotes the reference value. In (b), the bold solid red line represents the estimated log HR over time, and the thin red lines denote the 95 % confidence intervals. The solid black line represents the super-smoothed version of the log HR over time. Age is measured in years. The y-axis is in natural log scale; therefore, we present some examples of HRs to clinical interpretation: log (−1) = HR of 0.37, log (−0.5) = HR of 0.60, log (0) = HR of 1, log (1) = HR of 2.7 and log (2) = 7.4

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