Positiona
|
SNPs
|
Functionalityb
|
Minor allele
|
MAF
|
R
2
|
OR (95 % CI)
|
p value
|
---|
177,265,308
|
rs6721961
|
5′ flanking
|
T
|
0.111
|
0.32
|
1.93 (1.17–3.18)
|
0.0089
|
Histone mark, DHS
|
177,255,662
|
rs10188193
|
Intron 1
|
T
|
0.110
|
0.33
|
1.95 (1.19–3.17)
|
0.0071
|
177,255,583
|
rs10188107
|
Intron 1
|
T
|
0.110
|
0.33
|
1.95 (1.19–3.17)
|
0.0071
|
177,254,567
|
rs10497511
|
Intron 1
|
G
|
0.110
|
0.33
|
1.95 (1.19–3.17)
|
0.0070
|
DHS
|
177,253,821
|
rs2001297
|
Intron 1
|
C
|
0.110
|
0.33
|
1.95 (1.20–3.16)
|
0.0069
|
Histone mark
|
177,253,036
|
rs4243387c
|
Intron 1
|
C
|
0.112
|
0.34
|
1.93 (1.19–3.12)
|
0.0068
|
Histone mark
|
177,249,903
|
rs10930781c
|
Intron 1
|
A
|
0.106
|
0.35
|
1.90 (1.17–3.12)
|
0.0085
|
177,248,755
|
rs1962142c
|
Intron 1
|
A
|
0.103
|
0.33
|
1.96 (1.18–3.23)
|
0.0083
|
Histone mark
|
177,240,415
|
rs2364720
|
Intron 1
|
A
|
0.106
|
0.35
|
1.90 (1.17–3.09)
|
0.0082
|
Histone mark
|
177,235,696
|
rs2001350c
|
Intron 1
|
C
|
0.103
|
0.32
|
2.00 (1.20–3.35)
|
0.0075
|
Histone mark
|
-
CI confidence interval, DHS DNase I hypersensitivity site, FDR false discovery rate, MAF minor allele frequency, OR odds ratio, R
2 squared correlation between imputed and observed genotypes, SNP single-nucleotide polymorphism
-
aAccording to National Center for Biotechnology Genome Reference Consortium NCBI build GRCh38
-
bFunctionality obtained from HaploReg v3 [27]
-
cSNPs associated with primary graft dysfunction in Cantu et al. [11]