Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis

Table 3 Summary of NFE2L2 variants associated with acute respiratory distress syndrome susceptibility with false discovery rate <0.05

Position^a	SNPs	Functionality^b	Minor allele	MAF	R ²	OR (95 % CI)	p value
177,265,308	rs6721961	5′ flanking	T	0.111	0.32	1.93 (1.17–3.18)	0.0089
177,265,308	rs6721961	Histone mark, DHS	T	0.111	0.32	1.93 (1.17–3.18)	0.0089
177,255,662	rs10188193	Intron 1	T	0.110	0.33	1.95 (1.19–3.17)	0.0071
177,255,583	rs10188107	Intron 1	T	0.110	0.33	1.95 (1.19–3.17)	0.0071
177,254,567	rs10497511	Intron 1	G	0.110	0.33	1.95 (1.19–3.17)	0.0070
177,254,567	rs10497511	DHS	G	0.110	0.33	1.95 (1.19–3.17)	0.0070
177,253,821	rs2001297	Intron 1	C	0.110	0.33	1.95 (1.20–3.16)	0.0069
177,253,821	rs2001297	Histone mark	C	0.110	0.33	1.95 (1.20–3.16)	0.0069
177,253,036	rs4243387^c	Intron 1	C	0.112	0.34	1.93 (1.19–3.12)	0.0068
177,253,036	rs4243387^c	Histone mark	C	0.112	0.34	1.93 (1.19–3.12)	0.0068
177,249,903	rs10930781^c	Intron 1	A	0.106	0.35	1.90 (1.17–3.12)	0.0085
177,248,755	rs1962142^c	Intron 1	A	0.103	0.33	1.96 (1.18–3.23)	0.0083
177,248,755	rs1962142^c	Histone mark	A	0.103	0.33	1.96 (1.18–3.23)	0.0083
177,240,415	rs2364720	Intron 1	A	0.106	0.35	1.90 (1.17–3.09)	0.0082
177,240,415	rs2364720	Histone mark	A	0.106	0.35	1.90 (1.17–3.09)	0.0082
177,235,696	rs2001350^c	Intron 1	C	0.103	0.32	2.00 (1.20–3.35)	0.0075
177,235,696	rs2001350^c	Histone mark	C	0.103	0.32	2.00 (1.20–3.35)	0.0075

CI confidence interval, DHS DNase I hypersensitivity site, FDR false discovery rate, MAF minor allele frequency, OR odds ratio, R ² squared correlation between imputed and observed genotypes, SNP single-nucleotide polymorphism
^aAccording to National Center for Biotechnology Genome Reference Consortium NCBI build GRCh38
^bFunctionality obtained from HaploReg v3 [27]
^cSNPs associated with primary graft dysfunction in Cantu et al. [11]

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