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Table 3 Summary of NFE2L2 variants associated with acute respiratory distress syndrome susceptibility with false discovery rate <0.05

From: Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis

Positiona SNPs Functionalityb Minor allele MAF R 2 OR (95 % CI) p value
177,265,308 rs6721961 5′ flanking T 0.111 0.32 1.93 (1.17–3.18) 0.0089
Histone mark, DHS
177,255,662 rs10188193 Intron 1 T 0.110 0.33 1.95 (1.19–3.17) 0.0071
177,255,583 rs10188107 Intron 1 T 0.110 0.33 1.95 (1.19–3.17) 0.0071
177,254,567 rs10497511 Intron 1 G 0.110 0.33 1.95 (1.19–3.17) 0.0070
DHS
177,253,821 rs2001297 Intron 1 C 0.110 0.33 1.95 (1.20–3.16) 0.0069
Histone mark
177,253,036 rs4243387c Intron 1 C 0.112 0.34 1.93 (1.19–3.12) 0.0068
Histone mark
177,249,903 rs10930781c Intron 1 A 0.106 0.35 1.90 (1.17–3.12) 0.0085
177,248,755 rs1962142c Intron 1 A 0.103 0.33 1.96 (1.18–3.23) 0.0083
Histone mark
177,240,415 rs2364720 Intron 1 A 0.106 0.35 1.90 (1.17–3.09) 0.0082
Histone mark
177,235,696 rs2001350c Intron 1 C 0.103 0.32 2.00 (1.20–3.35) 0.0075
Histone mark
  1. CI confidence interval, DHS DNase I hypersensitivity site, FDR false discovery rate, MAF minor allele frequency, OR odds ratio, R 2 squared correlation between imputed and observed genotypes, SNP single-nucleotide polymorphism
  2. aAccording to National Center for Biotechnology Genome Reference Consortium NCBI build GRCh38
  3. bFunctionality obtained from HaploReg v3 [27]
  4. cSNPs associated with primary graft dysfunction in Cantu et al. [11]