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Table 1 Demographic and clinical characteristics of the study sample

From: Common variants of NFE2L2 gene predisposes to acute respiratory distress syndrome in patients with severe sepsis

Characteristic ARDS patients Controls p value
(n = 321) (n = 871)
Sex (% male)   63.2 59.6 0.242a
Median age, yr (P25–P75)   67 (55–75) 41 (32–49) <0.001b
Hypertension (%)   42.4 3.1 <0.001a
Smoker (%)   27.9 31.2 0.422a
Previous surgery (%)   65 NA  
Ischemic cardiac disease (%)   9.0 NA  
Source of sepsis (%)     
  Pulmonary 41.9 NA  
  Extrapulmonary 58.1 NA  
Pathogen (%)     
  Gram-negative 29.3 NA  
  Gram-positive 21.1 NA  
  Mixed 5.7 NA  
  Polymicrobial 3.3 NA  
  Virus 2.8 NA  
  Fungi 2.8 NA  
  Negative blood cultures 35.0 NA  
Organ dysfunction (%)     
  Circulatory 58.0 NA  
  Renal 43.6 NA  
  Hepatic 21.4 NA  
  Neurologic 20.8 NA  
  Coagulation 18.9 NA  
APACHE II, mean (P25–P75)   22 (17–27) NA  
PaO2/FiO2 mean,c mmHg (P25–P75)   206 (124–255)   
ICU mortality (%)   36.3 NA  
  1. APACHE II Acute Physiology and Chronic Health Evaluation II, ICU intensive care unit, NA not applicable, P25 percentile 25, P75 percentile 75, PaO2/FiO2 ratio of partial pressure arterial oxygen and fraction of inspired oxygen
  2. aχ2 test
  3. bMann–Whitney U test
  4. cAt the time of onset