Table 1 Demographic and clinical characteristics of the study sample
Characteristic | ARDS patients | Controls | p value | |
|---|---|---|---|---|
(n = 321) | (n = 871) | |||
Sex (% male) | 63.2 | 59.6 | 0.242a | |
Median age, yr (P25–P75) | 67 (55–75) | 41 (32–49) | <0.001b | |
Hypertension (%) | 42.4 | 3.1 | <0.001a | |
Smoker (%) | 27.9 | 31.2 | 0.422a | |
Previous surgery (%) | 65 | NA | ||
Ischemic cardiac disease (%) | 9.0 | NA | ||
Source of sepsis (%) | ||||
Pulmonary | 41.9 | NA | ||
Extrapulmonary | 58.1 | NA | ||
Pathogen (%) | ||||
Gram-negative | 29.3 | NA | ||
Gram-positive | 21.1 | NA | ||
Mixed | 5.7 | NA | ||
Polymicrobial | 3.3 | NA | ||
Virus | 2.8 | NA | ||
Fungi | 2.8 | NA | ||
Negative blood cultures | 35.0 | NA | ||
Organ dysfunction (%) | ||||
Circulatory | 58.0 | NA | ||
Renal | 43.6 | NA | ||
Hepatic | 21.4 | NA | ||
Neurologic | 20.8 | NA | ||
Coagulation | 18.9 | NA | ||
APACHE II, mean (P25–P75) | 22 (17–27) | NA | ||
PaO2/FiO2 mean,c mmHg (P25–P75) | 206 (124–255) | |||
ICU mortality (%) | 36.3 | NA | ||