Skip to main content

Table 1 Main characteristics of the included studies

From: Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis

Study

Year

Country

Sepsis definition

Sepsis diagnosis

Study population

Assay method

Cutoff

AUC

n

TP

FP

FN

TN

QUADAS

Dimoula et al. [11]

2014

Belgium

ISDCa

Clinical or provenb

Cases: patients with sepsis in ICU

FCM

MFI 230

0.94

468

92

47

11

318

11

Controls: SIRS patients without sepsis in ICU

Righi et al. [17]

2014

Italy

ISDC

Clinical or proven

Cases: patients with sepsis in ICU

FCM

2000 ABC

0.93

93

55

1

6

31

8

Controls: patients without sepsis in ICU

Gerrits et al. [13]

2013

Netherlands

ISDC

Proven

Cases: patients with sepsis in ICU

Hematology analyzer

1.66

NR

44

25

1

0

18

10

Controls: SIRS patients without sepsis in ICU

Gros et al. [15]

2012

France

ISDC

Proven

Cases: patients with sepsis in ICU

Leuko64 kit

2.2

0.80

293

93

16

55

129

10

Controls: SIRS patients without sepsis in ICU

Gibot et al. [14]

2012

France

ISDC

Clinical or proven

Cases: patients with sepsis in ICU

FCM

1.62

0.95

300

130

7

24

139

11

Controls: patients without sepsis in ICU

Hsu et al. [16]

2011

China

ISDC

Clinical or proven

Cases: patients with sepsis in ICU

FCM

4300 molecules/cell

0.93

66

49

1

6

10

9

Controls: SIRS patients without sepsis in ICU

Gámez-Díaz et al. [12]

2011

Colombia

ISDC

Clinical or proven

Cases: patients with sepsis in ED

Leuko64 kit

1.7

0.71

610

266

73

138

133

9

Controls: patients without sepsis in ED

Cardelli et al. [10]

2008

Italy

ISDC

Proven

Cases: patients with sepsis in ICU

FCM

2398 molecules/cell

0.97

112

50

5

2

55

9

Controls: patients without sepsis in ICU

  1. Abbreviations: ABC antibody-binding capacity, AUC area under the curve, ED emergency department, FCM flow cytometry, ICU intensive care unit, ISDC International Sepsis Definition Conference, MFI mean fluorescence intensity, QUADAS Quality Assessment of Diagnostic Accuracy Studies, SIRS systemic inflammatory response syndrome, TP true positive, FP false positive, FN false negative, TN true negative, NR not reported
  2. a2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference [27]
  3. b Clinical infection was defined as infection suspected on a clinical basis. Proven infection was defined as culture-proven infection with an identified microorganism