From: Neutrophil CD64 expression as a diagnostic marker for sepsis in adult patients: a meta-analysis
Study | Year | Country | Sepsis definition | Sepsis diagnosis | Study population | Assay method | Cutoff | AUC | n | TP | FP | FN | TN | QUADAS |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dimoula et al. [11] | 2014 | Belgium | ISDCa | Clinical or provenb | Cases: patients with sepsis in ICU | FCM | MFI 230 | 0.94 | 468 | 92 | 47 | 11 | 318 | 11 |
Controls: SIRS patients without sepsis in ICU | ||||||||||||||
Righi et al. [17] | 2014 | Italy | ISDC | Clinical or proven | Cases: patients with sepsis in ICU | FCM | 2000 ABC | 0.93 | 93 | 55 | 1 | 6 | 31 | 8 |
Controls: patients without sepsis in ICU | ||||||||||||||
Gerrits et al. [13] | 2013 | Netherlands | ISDC | Proven | Cases: patients with sepsis in ICU | Hematology analyzer | 1.66 | NR | 44 | 25 | 1 | 0 | 18 | 10 |
Controls: SIRS patients without sepsis in ICU | ||||||||||||||
Gros et al. [15] | 2012 | France | ISDC | Proven | Cases: patients with sepsis in ICU | Leuko64 kit | 2.2 | 0.80 | 293 | 93 | 16 | 55 | 129 | 10 |
Controls: SIRS patients without sepsis in ICU | ||||||||||||||
Gibot et al. [14] | 2012 | France | ISDC | Clinical or proven | Cases: patients with sepsis in ICU | FCM | 1.62 | 0.95 | 300 | 130 | 7 | 24 | 139 | 11 |
Controls: patients without sepsis in ICU | ||||||||||||||
Hsu et al. [16] | 2011 | China | ISDC | Clinical or proven | Cases: patients with sepsis in ICU | FCM | 4300 molecules/cell | 0.93 | 66 | 49 | 1 | 6 | 10 | 9 |
Controls: SIRS patients without sepsis in ICU | ||||||||||||||
Gámez-DÃaz et al. [12] | 2011 | Colombia | ISDC | Clinical or proven | Cases: patients with sepsis in ED | Leuko64 kit | 1.7 | 0.71 | 610 | 266 | 73 | 138 | 133 | 9 |
Controls: patients without sepsis in ED | ||||||||||||||
Cardelli et al. [10] | 2008 | Italy | ISDC | Proven | Cases: patients with sepsis in ICU | FCM | 2398 molecules/cell | 0.97 | 112 | 50 | 5 | 2 | 55 | 9 |
Controls: patients without sepsis in ICU |