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Table 2 Effect of esmolol on microcirculation of the E group compared to the C group

From: Gut and sublingual microvascular effect of esmolol during septic shock in a porcine model

Time

−60 min

 

60 min

 

270 min

 

Group effect

Time effect

Time/group effect

Group

Control

 

Esmolol

 

Control

 

Esmolol

 

Control

 

Esmolol

 

P value

P value

P value

Gut

               

MFI of the gut

2.6

(2.5 - 2.9)

2.8

(2.5 - 2.9)

1.5

(1.3 - 1.6)

1.8

(1.4 - 1.8)

1.1

(0.8 - 1.7)

2

(1.7 - 2.1)

0.129

<0.001

0.200

Ratio of perfused villi

0.9

(0.8 - 1)

1

(0.9 - 1)

0.7

(0.6 - 0.7)

0.7

(0.6 - 0.8)

0.5

(0.4 - 0.7)

0.8

(0.8 - 0.9)

0.006

<0.001

0.025

Heterogeneity index of the gut

10.3

(3 - 8.7)

18.8

(11.4 - 26.1)

68.6

(35.4 - 86.9)

48.6

(31.4 - 67.9)

81.8

(60 - 136.4)

73.5

(61.3 - 78)

0.267

0.001

0.376

Sublingual

               

TVD (n⋅mm)

18

(17.6 - 18.3)

16.1

(14.9 - 17.8)

12,9

(11,7 - 14,2)

11.4

(11.1 - 11.8)

15.9

(14.7 - 17)

15.9

(15.6 - 15.6)

0.270

0.822

0.931

TVD small vessels (n⋅mm)

14.7

(14.2 - 15.6)

12.3

(12.3 - 12.6)

11.8

(11.1 - 13.7)

10.3

(9.8 - 11.5)

12.8

(12.1 - 14.3)

12.2

(12.1 - 13.7)

0.074

0.262

0.141

TVD other vessels (n⋅mm)

2.4

(2 - 3)

3.4

(2.4 - 4.4)

0,6

(0,5 - 1,3)

1.0

(0.8 - 1.2)

2.5

(2 - 2.9)

3

(2.2 - 3.4)

0.022

0.074

0.151

PPV small vessels

94.1

(92.7 - 95.5)

87.3

(75.2 - 89.8)

63.7

(55.2 - 68.1)

64.6

(49.8 - 67.6)

75.5

(71.9 - 80.4)

77.5

(69.1 - 88.4)

0.568

0.183

0.212

PPV other vessels

100

(98.6 - 100)

98

(95.5 - 99.9)

92.7

(68.4 - 98.7)

98.5

(84.5 - 99.9)

97.4

(88.6 - 100)

96.8

(84.4 - 100)

0.772

0.63

0.757

MFI small vessels

2.8

(2.6 - 2.9)

2.7

(2.5 - 2.8)

1.7

(1.6 - 2.0)

1.5

(1.3 - 1.7)

2

(1.9 - 2.3)

2.1

(1.6 - 2.6)

0.528

0.07

0.542

MFI other vessels

3

(3 - 3)

2.9

(2.8 - 3)

2.8

(2.8 - 2.9)

2.9

(2.8 - 2.9)

2.8

(2.7 - 2.9)

2.8

(2.7 - 3)

0.552

0.051

0.491

Heterogeneity index

8.9

(4.4 - 17.1)

18

(6.5 - 26.8)

56.8

(38.6 - 97.4)

72.8

(37.8 - 78.9)

42

(29 - 60.7)

26.1

(18.2 - 33.5)

0.401

0.012

0.08

  1. Gut microcirculatory parameters were performed on the ileal mucosa through a stoma. Sublingual microcirculation was measured at the base of the tongue. The cut-off value to differentiate small vessels and other vessels is 20 μm. Density of vessel is performed by the De Backer score: six lines cross the image and three vertical and three horizontal vessels that cross the line are considered. The total of vessels crossing lines over total line length shows the density of vessels
  2. TVD, Total vessels density; MFI of the gut, Mean Flow Index of the ileal mucosa; MFI small vessels, sublingual Mean Flow Index of small vessels; MFI other vessels, Mean Flow Index of other vessels; Density small vessels, density of small vessels; Density other vessels, density of other vessels; PPV small vessels, proportion of perfused vessels for small vessels; PPV other vessels, proportion of perfused vessels for other vessels
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Critical Care

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