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Table 2 Effect of esmolol on microcirculation of the E group compared to the C group

From: Gut and sublingual microvascular effect of esmolol during septic shock in a porcine model

Time −60 min   60 min   270 min   Group effect Time effect Time/group effect
Group Control   Esmolol   Control   Esmolol   Control   Esmolol   P value P value P value
Gut                
MFI of the gut 2.6 (2.5 - 2.9) 2.8 (2.5 - 2.9) 1.5 (1.3 - 1.6) 1.8 (1.4 - 1.8) 1.1 (0.8 - 1.7) 2 (1.7 - 2.1) 0.129 <0.001 0.200
Ratio of perfused villi 0.9 (0.8 - 1) 1 (0.9 - 1) 0.7 (0.6 - 0.7) 0.7 (0.6 - 0.8) 0.5 (0.4 - 0.7) 0.8 (0.8 - 0.9) 0.006 <0.001 0.025
Heterogeneity index of the gut 10.3 (3 - 8.7) 18.8 (11.4 - 26.1) 68.6 (35.4 - 86.9) 48.6 (31.4 - 67.9) 81.8 (60 - 136.4) 73.5 (61.3 - 78) 0.267 0.001 0.376
Sublingual                
TVD (nmm) 18 (17.6 - 18.3) 16.1 (14.9 - 17.8) 12,9 (11,7 - 14,2) 11.4 (11.1 - 11.8) 15.9 (14.7 - 17) 15.9 (15.6 - 15.6) 0.270 0.822 0.931
TVD small vessels (nmm) 14.7 (14.2 - 15.6) 12.3 (12.3 - 12.6) 11.8 (11.1 - 13.7) 10.3 (9.8 - 11.5) 12.8 (12.1 - 14.3) 12.2 (12.1 - 13.7) 0.074 0.262 0.141
TVD other vessels (nmm) 2.4 (2 - 3) 3.4 (2.4 - 4.4) 0,6 (0,5 - 1,3) 1.0 (0.8 - 1.2) 2.5 (2 - 2.9) 3 (2.2 - 3.4) 0.022 0.074 0.151
PPV small vessels 94.1 (92.7 - 95.5) 87.3 (75.2 - 89.8) 63.7 (55.2 - 68.1) 64.6 (49.8 - 67.6) 75.5 (71.9 - 80.4) 77.5 (69.1 - 88.4) 0.568 0.183 0.212
PPV other vessels 100 (98.6 - 100) 98 (95.5 - 99.9) 92.7 (68.4 - 98.7) 98.5 (84.5 - 99.9) 97.4 (88.6 - 100) 96.8 (84.4 - 100) 0.772 0.63 0.757
MFI small vessels 2.8 (2.6 - 2.9) 2.7 (2.5 - 2.8) 1.7 (1.6 - 2.0) 1.5 (1.3 - 1.7) 2 (1.9 - 2.3) 2.1 (1.6 - 2.6) 0.528 0.07 0.542
MFI other vessels 3 (3 - 3) 2.9 (2.8 - 3) 2.8 (2.8 - 2.9) 2.9 (2.8 - 2.9) 2.8 (2.7 - 2.9) 2.8 (2.7 - 3) 0.552 0.051 0.491
Heterogeneity index 8.9 (4.4 - 17.1) 18 (6.5 - 26.8) 56.8 (38.6 - 97.4) 72.8 (37.8 - 78.9) 42 (29 - 60.7) 26.1 (18.2 - 33.5) 0.401 0.012 0.08
  1. Gut microcirculatory parameters were performed on the ileal mucosa through a stoma. Sublingual microcirculation was measured at the base of the tongue. The cut-off value to differentiate small vessels and other vessels is 20 μm. Density of vessel is performed by the De Backer score: six lines cross the image and three vertical and three horizontal vessels that cross the line are considered. The total of vessels crossing lines over total line length shows the density of vessels
  2. TVD, Total vessels density; MFI of the gut, Mean Flow Index of the ileal mucosa; MFI small vessels, sublingual Mean Flow Index of small vessels; MFI other vessels, Mean Flow Index of other vessels; Density small vessels, density of small vessels; Density other vessels, density of other vessels; PPV small vessels, proportion of perfused vessels for small vessels; PPV other vessels, proportion of perfused vessels for other vessels