Skip to main content

Table 1 Effect of bacterial infusion on hemodynamic and metabolic parameters

From: Gut and sublingual microvascular effect of esmolol during septic shock in a porcine model

  –T-60 min T 60 min P value
Hemodynamic    
HR (min−1) 97 (90 - 103) 117 (104 - 136) 0.007
MAP (mmHg) 64.9 (57.9 - 71.4) 71.2 (65.8 - 74.5) 0.106
MPAP (mmHg) 16.2 (14.9 - 19.1) 35.9 (31.5 - 38.8) 0.002
PCWP (mmHg) 7.6 (5.5 - 10.5) 8.6 (6.6 - 11.0) 0.307
CVP (mmHg) 9.9 (8.3 - 11.4) 11.3 (7.9 - 12.8) 1
CI (Lmin−1m−2) 2.4 (2.2 - 2.7) 2.9 (1.9 - 3.02) 0.62
SI (mLm−2) 24.6 (23.4 - 27.3) 21.1 (18.0 - 27.8) 0.151
SVR (dynscm5m−2) 2,458 (1,943 - 2,604) 2,344 (1,787 - 2,869) 0.577
PVR (dynscm5m−2) 161.6 (149.3 - 191) 358.7 (314.9 - 388.8) 0.002
Metabolic    
Lactate (mmolL−1) 2.1 (1.8 - 2.8) 1.7 (1.4 - 2.8) 0.045
O2ER (%) 14.0 (8.9 - 19.1) 14.1 (11.3 - 15.8) 0.432
O2ER/CI 5.5 (3.5 - 7.4) 4.8 (2.9 - 6.4) 0.622
PaO2/FiO2 (mmHg) 327.8 (253.3 - 436.4) 385.2 (240.4 - 422.3) 0.470
Gut microcirculation   
Videomicroscopy   
MFI of the gut 2.7 (2.5 - 2.9) 1.56 (1.25 - 1.75) 0.003
Heterogeneity index of the gut (%) 17.7 (4.7 - 33.4) 61.9 (27.5 - 72.3) <0.001
Ratio of perfused villi (%) 94.2 (90.0 - 97.7) 68.1 (59.0 - 76.5) 0.005
laser Doppler flow   
GMLDF (ua) 154.2 (85.9 - 699.6) 130.7 (80.15 - 674.7) 1
GMLDF variation 1.04 (0.87 - 1.08) 0.92 (0.85 - 1.18) 0.677
Sublingual microcirculation   
TVD (nmm) 17.7 (15.8 - 18.4) 11.7 (11.2 - 12.9) 0.021
MFI 2.8 (2.7 - 2.9) 2.2 (2.1 - 2.3) <0.001
MFI small vessels 2.7 (2.5 - 2.9) 1.6 (1.4 - 1.8) 0.003
MFI other vessels 3.0 (2.9 - 3.0) 2.8 (2.8 - 2.9) 0.036
Heterogeneity index (%) 13.2 (4.4 - 24.2) 64.6 (34.4 - 84.2) <0.001
PPV other vessels 99.7 (96.2 - 100) 96.03 (75.6 - 100) 0.262
PPV small vessels 91.9 (88.2 - 95.2) 64.6 (51.9 - 68.1) <0.001
  1. Hemodynamic parameters before and after the onset of sepsis but before esmolol administration. Wilcoxon test were performed to compare variables before and after sepsis. HR: heart rate, MAP: systemic mean arterial blood pressure, MPAP: mean pulmonary mean arterial blood pressure, PCWP: pulmonary capillary wedge pressure, CVP: Central venous pressure, SI: stroke index computed as CI/HR, SVR: systemic vascular resistance, CI: cardiac index, PVR: pulmonary vascular resistance, O2ER: oxygen extraction ratio, FiO2: fraction of inspired oxygen, GMLDF: gut microcirculatory laser Doppler flow, TVD: total vessels density, MFI: microvascular flow index. Ratio of perfused villi: proportion of perfused villi, PPV: proportion of perfused vessels, small vessels: vessels with a diameter under 20 μm, Other vessels: vessels with a diameter above 20 μm, mmHg: millimeters of mercury, mmolL−1: millimolesLiter, PaO2: arterial partial pressure of oxygen