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Fig. 2 | Critical Care

Fig. 2

From: Gut and sublingual microvascular effect of esmolol during septic shock in a porcine model

Fig. 2

Evolution of hemodynamic variables during the experiment. T-60 min is the beginning of stabilization; T 0 min is the time of bacterial injection. Esmolol is started and hemodynamic stabilization occurs between T 60 and T 180 min after resuscitation is started, and the experiment concluded at T 300 min. ANOVA were performed for each parameter: (a) HR, group effect P <0.001, time effect P = 0.223, time/group effect P = 0.004; (b) SI, group effect P = 0.222, time effect P = 0.050, time/group effect P = 0.404; (c) CI, group effect P = 0.006, time effect P = 0.508, time/group effect P = 0.339; (d) MAP, group effect P = 0.099, time effect P = 0.042, time/group effect P = 0.051; (e) SVR, group effect P = 0.662, time effect P = 0.023, time/group effect P = 0.004; HR, heart rate; CI, cardiac index; SI, stroke index computed as CI/HR; MAP, systemic mean arterial blood pressure; SI, stroke index computed as CI/HR; SVR, systemic vascular resistance

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