Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy

Table 4 Univariate and multivariate logistic regression analysis of clinical variables associated with hospital mortality

Parameter	Beta coefficient	Standard error	Odds ratio (95 % CI)	p value
Univariate logistic regression
Age	0.013	0.012	1.014 (0.989, 1.038)	0.272
Male gender	−0.491	0.423	0.612 (0.267, 1.402)	0.246
Immunocompromised	0.575	0.460	1.778 (0.721, 4.381)	0.211
SOFA score, diagnosis day	0.130	0.071	1.139 (0.991, 1.307)	0.066
PaO₂/FiO₂, diagnosis day	0.003	0.003	1.003 (0.996, 1.010)	0.423
SOFA score, biopsy day	0.326	0.085	1.385 (1.173, 1.635)	<0.001*
PaO₂/FiO₂, biopsy day	−0.007	0.003	0.993 (0.987, 0.999)	0.03*
Treatment changes after biopsy	−0.770	0.415	0.463 (0.205, 1.044)	0.063
DAD on biopsy	1.123	0.423	3.075 (1.343, 7.039)	0.008*
Multivariate logistic regression
DAD on biopsy	1.268	0.481	3.554 (1.385, 9.120)	0.008*
SOFA score, biopsy day	0.353	0.093	1.424 (1.187, 1.707)	<0.001*
Constant	−2.522	0.698	0.080	<0.001*

*p <0.05. In multivariate logistic regression, the Hosmer-Lemeshow test results (χ² = 3.371, degrees of freedom = 8, p = 0.909). Abbreviations: SOFA Sequential organ failure assessment, PaO₂ Arterial partial pressure of oxygen, FiO₂ fraction of inspired oxygen, DAD diffuse alveolar damage

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