Diffuse alveolar damage associated mortality in selected acute respiratory distress syndrome patients with open lung biopsy

Table 3 Demographic and clinical characteristics of survivors versus. non-survivors in patients with ARDS who had open lung biopsy

Characteristics	Survivors (n=40)	Non-survivors (n=61)	P value
Age	54.5 ± 15.4	58.3 ± 17.6	0.274
Gender (male/female)	23/17	42/19	0.244
Immunocompromised (%)	32.5	21.3	0.208
APACHE II score, diagnosis day	23.4 ± 5.3	23.1 ± 5.7	0.838
SOFA score, diagnosis day	5.4 ± 2.6	6.6 ± 3.5	0.06
PaO₂/FiO₂ (mm Hg), diagnosis day	136.5 ± 55.3	146.3 ± 63.4	0.427
SOFA score, biopsy day	5.2 ± 2.7	8.1 ± 3.4	<0.001*
PaO₂/FiO₂ (mm Hg), biopsy day	167.6 ± 69.3	136.3 ± 64.6	0.023*
PEEP (cm H₂O), biopsy day	11.2 ± 2.7	12.2 ± 2.7	0.071
Tidal volume (mL), biopsy day	437.1 ± 86.0	413.4 ± 107.2	0.372
Duration from diagnosis to biopsy (days)	7.1 ± 6.4	8.1 ± 7.1	0.232
Operative complication rate (%)	5	18	0.056
DAD on biopsy (%)	40	67.2	0.007*
Treatment changes after biopsy (%)	60	41	0.061

All values are expressed as number of patients (%) or mean ± SD; *p values <0.05. Abbreviations: ARDS Acute respiratory distress syndrome, APACHE Acute physiology and chronic health evaluation; SOFA Sequential organ failure assessment, PaO₂ Arterial partial pressure of oxygen, FiO₂ Fraction of inspired oxygen, PEEP Positive end-expiratory pressure, DAD Diffuse alveolar damage

ISSN: 1364-8535