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Fig. 8 | Critical Care

Fig. 8

From: Experimental acute lung injury induces multi-organ epigenetic modifications in key angiogenic genes implicated in sepsis-associated endothelial dysfunction

Fig. 8

Proposed model for sepsis-induced downregulated transcription of angiogenic genes in endothelial cells and pericytes. Constitutively, epigenetic modifiers, including those that maintain permissive histone acetylation, are bound to genes by transcription factors and polymerase II (Pol II) machinery. During sepsis, systemic release of pathogen-associated molecular pattern molecules (PAMPs) or endogenous danger-associated molecular pattern molecules (DAMPs) or both initiates signal pathways that reduce activity of gene-bound transcription initiation or elongation factors or both. These transcription factor changes alter the balance of modifiers, shifting open chromatin toward more compact structures and contributing to downregulation of Pol II transcription of Tek and Kdr in endothelial cells and Angpt1 in pericytes

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Critical Care

ISSN: 1364-8535