Diagnostic value of neutrophil gelatinase-associated lipocalin, cystatin C, and soluble triggering receptor expressed on myeloid cells-1 in critically ill patients with sepsis-associated acute kidney injury

Table 2 Acute kidney injury risk indicated by these biomarkers in septic patients analyzed by using logistic regression with generalized estimating equations

Variable	Crude: model 1^a		Adjusted: model 2^b		Adjusted: model 3^c
Variable	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Plasma NGAL	1.013 (1.010-1.015)	<0.001	1.012 (1.009-1.014)	<0.001	1.013 (1.010-1.022)	<0.001
Urine NGAL	1.030 (1.014-1.047)	<0.001	1.029 (1.014-1.045)	<0.001	1.027 (1.011-1.044)	0.001
Plasma Cys-C^d	1.003 (1.002-1.004)	0.001	1.003 (1.002-1.003)	0.001	1.003 (1.002-1.003)	<0,001
Urine Cys-C^d	1.010 (1.005-1.014)	<0.001	1.024 (1.018-1.038)	<0.001	1.022 (1.008-1.035)	0.001
Plasma sTREM-1	1.029 (1.021-1.037)	<0.001	1.023(1.016-1.031)	<0.001	1.028(1.018-1.037)	<0.001
Urine sTREM-1	1.038(1.019-1/057	<0.001	1.033(1.016-1.050	<0.001	1.031(1.009-1.053)	0.005

^aNot adjusted. ^bAdjusted for serum creatinine (SCr). ^cAdjusted for mean arterial pressure, Acute Physiology and Chronic Health Evaluation II scores, Sequential Organ Failure Assessment scores, and procalcitonin in addition to SCr. ^dOdds ratio (ORs) represent the increase in risk per 0.001 mg/L increase in cystatin C (Cys-C). CI, confidence interval; NGAL, neutrophil gelatinase-associated lipocalin; sTREM-1, soluble triggering receptor expressed on myeloid cells-1.

ISSN: 1364-8535