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Table 1 Fatty acids in the plasma and monocyte membranes

From: Immunomodulation by lipid emulsions in pulmonary inflammation: a randomized controlled trial

  

Time, hours

 

Group

0

8

24

Free fatty acid, μmol/l

    

AA

NaCl

4.0 ± 0.6

3.3 ± 0.3

4.9 ± 1.0

 

SO

4.0 ± 0.6

4.0 ± 0.7

4.6 ± 1.3

 

FO

4.3 ± 0.5

4.2 ± 0.8

5.0 ± 1.1

EPA

NaCl

0.6 ± 0.1

0.3 ± 0.0

0.4 ± 0.1

 

SO

0.6 ± 0.1

0.5 ± 0.1

0.7 ± 0.2

 

FO

0.7 ± 0.2

3.4 ± 0.8ab

2.5 ± 0.4ab

DHA

NaCl

0.8 ± 0.1

0.6± 0.2

0.9 ± 0.2

 

SO

0.8 ± 0.1

0.9 ± 0.1

1.0 ± 0.2

 

FO

0.9 ± 0.1

2.2 ± 0.3a b

3.0 ± 0.7a b

Sum

NaCl

335.1 ± 50.2

336.8 ± 42.4

408.6 ± 74.3

 

SO

346.0 ± 53.9

372.1 ± 42.1

366.5 ± 59.8

 

FO

377.4 ± 44.1

250.1 ± 29.8

348.3 ± 83.0

Membrane fatty acid. %

    

AA

NaCl

19.7 ± 0.5

19.2 ± 0.6

18.5 ± 0.5

 

SO

19.4 ± 0.4

18.0 ± 0.8

20.0 ± 0.3

 

FO

19.4 ± 0.6

17.1 ± 0.8a

17.4 ± 1.1a

EPA

NaCl

0.2 ± 0.0

0.1 ± 0.0

0.1 ± 0.0

 

SO

0.2 ± 0.0

0.1 ± 0.0

0.2 ± 0.0

 

FO

0.2 ± 0.0

1.9 ± 0.2a b

1.3 ± 0.1a b

DHA

NaCl

2.6 ± 0.1

2.4 ± 0.3

2.3 ± 0.2

 

SO

2.9 ± 0.2

2.5 ± 0.3

2.8 ± 0.4

 

FO

3.1 ± 0.2

4.8 ± 0.2a b

4.7 ± 0.4a b

  1. Plasma and isolated monocytes originated from volunteers receiving fish oil (FO)- or soybean oil (SO)-based lipid infusion, or normal saline (NaCl). Free fatty acids (AA, arachidonic acid; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid) and membrane fatty acids were determined by gas chromatography: a P <0.05 versus baseline; b P <0.05 versus SO and NaCl. Data are presented as mean +/- standard error of the mean; n =12 for baseline and n = 5 – 6 for later time points.