Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort

Tridente, Ascanio; Clarke, Geraldine M; Walden, Andrew; Gordon, Anthony C; Hutton, Paula; Chiche, Jean-Daniel; Holloway, Paul AH; Mills, Gary H; Bion, Julian; Stüber, Frank; Garrard, Christopher; Hinds, Charles

doi:10.1186/s13054-015-0931-8

Critical Care

Table 1 Trends in variables during first 7 days of intensive care unit stay^a

From: Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort

			Day 1			Day 7
Characteristics			N	n or median	% or IQR	N	n or median	% or IQR
Organ failure and support
	ARF		974	283	29.1%	659	159	24.1%
	RRT		974	115	11.8%	659	104	15.8%
	Ventilatory support		974	743	76.3%	657	413	62.9%
	Inotrope/vasopressor use^b		974			660
		None		267	27.4%		434	65.8%
		A		33	3.4%		36	5.5%
		B		169	17.4%		105	15.9%
		C		505	51.9%		85	12.9%
	SOFA		974	7	5 to 10	659	5	2 to 8
		GCS SOFA	974	0	0 to 1	674	0	0 to 1
		CVS SOFA	974	4	1 to 4	671	1	0 to 3
		Coagulation SOFA	974	0	0 to 1	674	0	0 to 1
		Respiratory SOFA	974	2	2 to 3	659	2	1 to 3
		Renal SOFA	974	1	0 to 2	674	0	0 to 1
		Bilirubin SOFA	974	0	0 to 1	674	0	0 to 0
Laboratory variables
	Serum bicarbonate		893	21	18 to 24	580	26	23 to 29.1
	paO₂ (kPa)		945	11.3	9.6 to 13.9	590	10.8	9.2 to 13.6
	paCO₂ (kPa)		938	5.2	4.6 to 6	535	5.2	4.7 to 6
	Highest creatinine (μmol/L)		974	106.6	76 to 160	654	81.5	53.9 to 132
	Lowest creatinine (μmol/L)		974	100	70 to 144	642	81.5	54 to 130
	Highest WCC (10⁻⁹/L)		974	12	7.1 to 18	643	15.3	11 to 20.4
	Lowest WCC (10⁻⁹/L)		974	9.4	4.6 to 15	643	15	10.5 to 20
	Lowest platelets (10⁻⁹/L)		974	212.5	145 to 300	640	234.5	132 to 352.5
	Highest bilirubin (mmol/L)		974	13	8 to 22	650	10	5 to 19
	Highest urea (mmol/L)		908	11	6.4 to 17.1	607	11.6	7.2 to 20.8
Chest radiography findings
	Localised infiltrates		973	115	11.8%	672	68	10.1%
	Lobar infiltrates		973	61	6.3%	672	32	4.8%
	Diffuse bilateral infiltrates		973	148	15.2%	672	109	16.2%
Physiological parameters
	Highest temperature (°C)		974	37.7	37 to 38.3	656	37.4	37 to 38
	Lowest temperature (°C)		974	36.2	35.7 to 36.9	656	36.5	36 to 37
	Highest SBP (mmHg)		974	140	125 to 155	655	150	135 to 170
	Lowest SBP (mmHg)		972	90	80 to 100	655	108	95 to 120
	Highest MAP (mmHg)		972	91	82 to 103	649	98	89 to 110
	Lowest MAP (mmHg)		970	62	56 to 70	649	71	63 to 80
	Highest heart rate (bpm)		974	117	103 to 130	655	104	90 to 118
	Lowest heart rate (bpm)		971	85	73 to 99	655	80	70 to 90
	Respiratory rate (breaths/min)		966	18	14 to 24	638	20	16 to 27
	Urinary volume (ml/24 hr)		973	1,375	790 to 2,100	644	2,276.5	1,333.5 to 3,411.5
	paO₂/FiO₂ ratio (kPa)		942	27.8	19.6 to 37.7	573	30.7	23.1 to 39.2

^aARF, Acute renal failure; bpm, Beats per minute; CVS, Cardiovascular; GCS, Glasgow Coma Scale; IQR, Interquartile range; MAP, Mean arterial pressure; n, Absolute count; N, Number of non-missing observations; paCO₂, Arterial partial pressure of carbon dioxide; paO₂, Arterial partial pressure of oxygen; paO₂/FiO₂, Ratio of partial pressure of arterial oxygen to fraction of inspired oxygen; RRT, Renal replacement therapy; SBP, Systolic blood pressure; SOFA, Sequential Organ Failure Assessment; WCC, White cell count. ^bInotropic and vasopressor use is coded as follows: A = dopamine ≤5 μg/kg/min or dobutamine; B = dopamine >5 μg/kg/min or adrenaline/noradrenaline ≤0.1 μg/kg/min; C = dopamine >15 μg/kg/min or adrenaline/noradrenaline >0.1 μg/kg/min.

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ISSN: 1364-8535

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