Trends in variables independently associated with 6-month survival (primary outcome). (A1) to (A3) Daily lowest platelet count, 24-hour urinary volume and highest recorded bilirubin concentration. The boxes indicate median and interquartile range (IQR), the whiskers extend to include 1.5× IQR and the dots include outliers outside this range. (B1) and (B2) Daily Glasgow Coma Scale (GCS) score and renal components of the Sequential Organ Failure Assessment (SOFA) score. Proportions of different values of the renal and GCS components of the SOFA are indicated for survivors and non-survivors.