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Table 3 Cox regression analysis for in-hospital survival (left) and two-year survival (right)

From: Early deep sedation is associated with decreased in-hospital and two-year follow-up survival

  Cox regression for in-hospital survival Cox regression for two-year follow-up survival
  P HR 95% CI P HR 95% CI
Deep sedation during first 48 h on ICU 0.022 1.661 1.074-2.567 <0.001 1.866 1.351-2.576
APACHE II on ICU admission <0.001 1.051 1.030-1.073 <0.001 1.045 1.028-1.062
Age [y] 0.072 1.011 0.999-1.022 0.001 1.016 1.007-1.026
Male gender 0.132 0.764 0.538-1.084 0.024 1.375 1.043-1.812
Body mass index 0.043 0.973 0.947-0.999 0.064 0.978 0.955-1.001
Admission: emergency surgery 0.398 0.408 0.051-3.264 0.960 1.021 0.449-2.321
Admission: medical 0.421 1.355 0.647-2.837 0.950 1.016 0.626-1.647
Inotropics: dopamine ≤=5 0.226 1.538 0.766-3.090 0.970 0.991 0.614-1.600
Inotropics: dopamine >5 or E/NE ≤=0.1 0.102 1.473 0.926-2.344 0.764 0.948 0.670-1.341
Inotropics: dopamine >15 or E/NE >0.1 0.321 1.270 0.792-2.037 0.041 1.441 1.015-2.046
Sedatives: propofol 0.877 0.972 0.675-1.399 0.189 1.224 0.905-1.654
Sedatives: midazolam 0.618 1.272 0.494-3.277 0.497 0.823 0.469-1.444
Sedatives: both 0.265 1.779 0.646-4.902 0.326 1.388 0.722-2.667
Haemodialysis during first 48 h on ICU 0.416 1.502 0.564-3.998 0.600 0.850 0.464-1.560
  1. Regression analysis of factors influencing in-hospital and long-term mortality in matched cohort. Reference category for type of admission: elective surgery, for inotropics: neither dopamine, epinephrine nor epinephrine, for sedatives: none. HR, hazard ratio; CI, confidence interval; APACHE II, Acute Physiology and Chronic Health Evaluation; ICU, intensive care unit; E, epinephrine; NE, norepinephrine.