Table 3 Evolution of hepatosplanchnic flow and perfusion parameters at different time points

SpO₂ (%)

Sham

86 (74–90)

86 (76–91)

79 (76–85)

78 (74–89)

0.64

LPS

85 (75–91)

81 (75–86)

76 (65–85)

66 (53–72)^b

0.08

ShO₂ (%)

Sham

73 (62–87)

69 (65–80)

75 (64–81)

72 (55–84)

0.43

LPS

77 (69–80)

75 (72–84)

71 (63–73)

68 (46–80)

0.25

Portal lactate (mmol/L)

Sham

1.2 (0.6-2.2)

2.2 (1.1-3.8)

1.8 (0.9-3.5)

1.3 (1.1-2.9)

0.31

LPS

2.6 (2.0-3.8)^b

4 (3.3-6.3)^b

6.4 (5.8-8.2)^b

8.3 (7–9.5)^b

0.06

Hepatic lactate (mmol/L)

Sham

1.3 (0.6-3.1)

1.9 (0.8-3.8)

1.6 (1.1-2.8)

1.2 (1–2.5)

0.52

LPS

2.1 (1.6-2.9)

4.1 (3.3-6.3)^b

6.1 (5.1-7.7)^b

7.3 (6.4-8.6)^b

0.04

Hepatic DO₂ (ml O₂/min)

Sham

117 (53–150)

107 (50–160)

93 (55–128)

88 (42–150)

0.10

LPS

98 (68–133)

97 (75–110)

76 (52–88)

56 (36–70)

0.03

Hepatic VO₂ (ml O₂/min)

Sham

34 (16–49)

28 (13–45)

34 (10–41)

38 (13–41)

0.21

LPS

20 (11–34)

24 (20–30)

28 (17–37)

22 (19–25)

0.7

Hepatic O₂ER (%)

Sham

0.33 (0.25-0.37)

0.33 (0.19-0.45)

0.46 (0.30-058)

0.34 (0.22-0.59)

0.81

LPS

0.25 (0.10-0.35)

0.22 (0.20-0.34)

0.37 (0.32-0.44)

0.42 (0.30-0.73)

0.34

Total hepatic blood flow (ml/min)

Sham

707 (585–1,335)

770 (660–1,250)

732 (673–1,213)

655 (593–1,175)

0.40

LPS

1,150 (753–1,568)

1,275 (1,181-1,700)

1,050 (880–1,227)

915 (773–1,046)

0.048

Fractional hepatic blood flow (%)

Sham

47 (32–62)

41 (34–47)

39 (30–48)

46 (35–57)

0.43

LPS

50 (43–56)

41 (39–44)

35 (31–43)

32 (26–43)^b

0.08