Impairment of exogenous lactate clearance in experimental hyperdynamic septic shock is not related to total liver hypoperfusion

Table 2 Evolution of serum lactate, sorbitol, and lactate clearances at different time points

Variable	Group	A	B	C	D	P^a
Arterial lactate (mmol/L)	Sham	2.4 (1.5-4.3)	1.8 (1.5-3.7)	2.2 (1.8-4.7)	2 (1.8-3.3)	0.8
Arterial lactate (mmol/L)	LPS	2.8 (2–3.6)	4.7 (3.1-6.7)^b	7.1 (5.1-9.4)^b	10.2 (7.8-12.3)^b	0.01
Sorbitol clearance (ml/min)	Sham	582 (327–739)	385 (221–1,060)	NA	453 (348–612)	0.5
Sorbitol clearance (ml/min)	LPS	481 (354–506)	519 (333–578)	NA	581 (318–824)	0.23
Lactate clearance (ml/min)	Sham	1,299 (418–2,187)	1212 (743–2,116)	NA	944 (363–1,235)	0.60
Lactate clearance (ml/min)	LPS	1,066 (108–1,660)	46 (30–180)^b	NA	113 (65–322)^b	0.01

Values are presented as median (interquartile range). P <0.05 considered as significant. ^aSignificant changes over time within groups. Comparison made with Friedman’s test and Bonferroni’s post-hoc correction. ^bSignificant difference between groups at the same time point. Comparison made with Mann–Whitney U test. LPS, lipopolysaccharide.

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