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Table 1 Clinical and epidemiological characteristics of multidrug (MDR) and non-multidrug resistant patients with Pseudomonas aeruginosa pneumonia

From: An international multicenter retrospective study of Pseudomonas aeruginosa nosocomial pneumonia: impact of multidrug resistance

Characteristic Percent missing (of total 740) MDR N = 226 Non-MDR N = 514 P -value
Age, years, mean ± SD 0.5%a 53.5 ± 17.5 62.1 ± 15.5 <0.001
Male 0% 142 (62.8%) 361 (70.2%) 0.047
Location prior to admission 1.1%    
 Community   101 (44.7%) 286 (55.6%) 0.006
 Skilled nursing facility   17 (7.5%) 37 (7.2%) 0.876
 Long-term care facility   7 (3.1%) 20 (3.9%) 0.596
 Assisted living   4 (1.8%) 3 (0.6%) 0.125
 Inpatient rehabilitation   27 (11.9%) 20 (3.9%) <0.001
 Other   66 (29.2%) 144 (28.0%) 0.741
Past medical history     
 Hospitalized in the previous 6 months 13.1% 126 (60.6%) 245 (56.3%) 0.307
 Antibiotics in the previous 30 days 27.6% 100 (57.5%) 163 (45.0%) 0.007
 Heart failure 9.6% 49 (23.2%) 131 (28.6%) 0.145
 Chronic obstructive pulmonary disease 9.2% 102 (48.8%) 173 (37.4%) 0.005
 Diabetes mellitus 8.6% 79 (37.8%) 137 (29.3%) 0.029
 Chronic kidney disease 9.3% 55 (26.3%) 118 (25.5%) 0.832
 Chronic liver disease 11.9% 38 (18.5%) 70 (15.7%) 0.359
 Hematologic malignancy 9.9% 20 (9.4%) 40 (8.8%) 0.807
 Solid tumor 10.3% 18 (8.7%) 81 (17.7%) 0.002
 HIV/AIDS 10.5% 3 (1.5%) 6 (1.3%) 0.885
 Dementia 12.6% 6 (3.0%) 36 (8.1%) 0.015
Charlson score, mean ± SD 2.6% 3.1 ± 2.6 3.0 ± 2.6 0.869
Pneumonia category 0%    
 Community-onset, healthcare-associated   74 (32.7%) 167 (32.5%) 0.946
 Hospital-onset   152 (67.2%) 347 (67.5%) 0.946
  Hospital-acquired   50 (22.1%) 112 (21.8%) 0.919
  Ventilator-associated   102 (45.1%) 235 (45.7%) 0.883
ICU admission 0% 180 (79.6%) 367 (71.4%) 0.019
Length of ICU stay, days, median (IQR) 0% 18.9 (11.4, 32.5) 16.1 (8.7, 29.1) 0.058
Mechanical ventilation 0% 197 (87.2%) 440 (85.6%) 0.571
Length of mechanical ventilation, days, median (IQR) 0% 17.0 (9.1, 34.1) 13.1 (6.5, 26.0) 0.006
Vasopressor administration 0% 146 (64.6%) 308 (59.9%) 0.229
Bacteremia 0% 53 (23.5%) 128 (24.9%) 0.672
Inappropriate initial antibiotic therapy 1.5% 83 (37.9%) 98 (19.2%) <0.001
In-hospital mortality 0% 101 (44.7%) 163 (31.7%) 0.001
Length of hospital stay, days, median (IQR) 0% 27.0 (14.0, 56.3) 25.0 (13.0, 46.0) 0.090
  1. aFour patients aged >90 years (one MDR, three non-MDR) were not included in the calculation.