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Table 2 Cox and logistic regression analyses for FGF23 tertiles and mortality during follow-up, postoperative acute kidney injury and non-occlusive mesenteric ischaemiaa

From: A single preoperative FGF23 measurement is a strong predictor of outcome in patients undergoing elective cardiac surgery: a prospective observational study

Model

FGF23

Mortality

AKIb

NOMIc

  

HR (95% CI)

P -value

HR (95% CI)

P -value

HR (95% CI)

P -value

Crude

Tertile 1

1

–

1

–

1

–

 

Tertile 2

1.86 (0.82 to 4.21)

0.137

2.23 (1.42 to 3.51)

<0.001

1.83 (0.85 to 3.92)

0.121

 

Tertile 3

4.40 (2.11 to 9.18)

<0.001

6.26 (4.08 to 9.59)

<0.001

4.79 (2.42 to 9.48)

<0.001

Adjusted model 1d

Tertile 1

1

–

1

–

1

–

 

Tertile 2

1.46 (0.64 to 3.36)

0.370

1.94 (1.21 to 3.10)

0.006

1.53 (0.71 to 3.32)

0.281

 

Tertile 3

3.05 (1.42 to 6.55)

0.004

4.89 (3.09 to 7.72)

<0.001

3.44 (1.69 to 7.02)

0.001

Adjusted model 2e

Tertile 1

1

–

1

–

1

–

 

Tertile 2

1.35 (0.59 to 3.11)

0.482

1.65 (1.01 to 2.67)

0.044

1.24 (0.56 to 2.75)

0.590

 

Tertile 3

2.34 (1.07 to 5.29)

0.034

2.69 (1.62 to 4.47)

<0.001

2.76 (1.30 to 5.85)

0.008

Adjusted model 3f

Tertile 1

1

–

1

–

1

–

 

Tertile 2

1.88 (0.83 to 4.25)

0.131

1.96 (1.24 to 3.10)

0.004

1.59 (0.74 to 3.42)

0.239

 

Tertile 3

4.54 (2.18 to 9.45)

<0.001

4.67 (3.00 to 7.27)

<0.001

3.71 (1.84 to 7.48)

<0.001

  1. aAKI, Acute kidney injury; CI, Confidence interval; FGF23, Fibroblast growth factor 23; HR, Hazard ratio; NOMI, Non-occlusive mesenteric ischaemia; RU, Relative units. FGF23 tertile 1: ≤50.6 RU/ml, tertile 2: 50.7 to 89.9 RU/ml, tertile 3: ≥90 RU/ml. bc-Statistics for the prediction of AKI in adjusted model 3: 0.690. cc-Statistics for the prediction of NOMI in adjusted model 3: 0.590. dAdjusted for age and sex. eAdjusted for age, sex, mean arterial blood pressure, sinus rhythm, coronary artery disease, chronic heart failure, diabetes, serum creatinine and serum high-sensitivity C-reactive protein. fAdjusted for EuroSCORE II, comprising 18 variables as described in the Methods section.