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Table 2 Cox and logistic regression analyses for FGF23 tertiles and mortality during follow-up, postoperative acute kidney injury and non-occlusive mesenteric ischaemiaa

From: A single preoperative FGF23 measurement is a strong predictor of outcome in patients undergoing elective cardiac surgery: a prospective observational study

Model FGF23 Mortality AKIb NOMIc
   HR (95% CI) P -value HR (95% CI) P -value HR (95% CI) P -value
Crude Tertile 1 1 1 1
  Tertile 2 1.86 (0.82 to 4.21) 0.137 2.23 (1.42 to 3.51) <0.001 1.83 (0.85 to 3.92) 0.121
  Tertile 3 4.40 (2.11 to 9.18) <0.001 6.26 (4.08 to 9.59) <0.001 4.79 (2.42 to 9.48) <0.001
Adjusted model 1d Tertile 1 1 1 1
  Tertile 2 1.46 (0.64 to 3.36) 0.370 1.94 (1.21 to 3.10) 0.006 1.53 (0.71 to 3.32) 0.281
  Tertile 3 3.05 (1.42 to 6.55) 0.004 4.89 (3.09 to 7.72) <0.001 3.44 (1.69 to 7.02) 0.001
Adjusted model 2e Tertile 1 1 1 1
  Tertile 2 1.35 (0.59 to 3.11) 0.482 1.65 (1.01 to 2.67) 0.044 1.24 (0.56 to 2.75) 0.590
  Tertile 3 2.34 (1.07 to 5.29) 0.034 2.69 (1.62 to 4.47) <0.001 2.76 (1.30 to 5.85) 0.008
Adjusted model 3f Tertile 1 1 1 1
  Tertile 2 1.88 (0.83 to 4.25) 0.131 1.96 (1.24 to 3.10) 0.004 1.59 (0.74 to 3.42) 0.239
  Tertile 3 4.54 (2.18 to 9.45) <0.001 4.67 (3.00 to 7.27) <0.001 3.71 (1.84 to 7.48) <0.001
  1. aAKI, Acute kidney injury; CI, Confidence interval; FGF23, Fibroblast growth factor 23; HR, Hazard ratio; NOMI, Non-occlusive mesenteric ischaemia; RU, Relative units. FGF23 tertile 1: ≤50.6 RU/ml, tertile 2: 50.7 to 89.9 RU/ml, tertile 3: ≥90 RU/ml. bc-Statistics for the prediction of AKI in adjusted model 3: 0.690. cc-Statistics for the prediction of NOMI in adjusted model 3: 0.590. dAdjusted for age and sex. eAdjusted for age, sex, mean arterial blood pressure, sinus rhythm, coronary artery disease, chronic heart failure, diabetes, serum creatinine and serum high-sensitivity C-reactive protein. fAdjusted for EuroSCORE II, comprising 18 variables as described in the Methods section.