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Figure 6 | Critical Care

Figure 6

From: Kallistatin treatment attenuates lethality and organ injury in mouse models of established sepsis

Figure 6

Kallistatin treatment ameliorates liver injury, attenuates serum alanine transaminase (ALT) levels, and reduces tumor necrosis factor-α (TNF-α) and toll-like receptor-4 (TLR4) expression in liver tissue of LPS-induced endotoxemic mice. (A) H&E staining was performed on liver sections to examine histology (n = 4). The representative sections are shown at ×200 magnification. (B) Kallistatin administration reduces serum ALT levels (n = 3 to 4). Liver mRNA levels of (C) TNF-α and (D) TLR4 were significantly decreased by kallistatin treatment (n = 3). *P <0.05 versus control group; # P <0.05 versus LPS control group.

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