Skip to main content
Figure 5 | Critical Care

Figure 5

From: Kallistatin treatment attenuates lethality and organ injury in mouse models of established sepsis

Figure 5

Delayed kallistatin treatment reduces renal injury, serum creatinine, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and high mobility group box-1 (HMGB1) levels, and increases renal suppressor of cytokine signaling-3 (SOCS3) expression in endotoxemic mice. (A) H&E staining was performed on kidney sections to examine histology (n = 4). The representative sections are shown at ×200 magnification. (B) Serum creatinine levels were attenuated by kallistatin treatment. (C) TNF-α, (D) IL-6 and (E) HMGB1 levels in serum of kallistatin-treated mice were significantly lower than that of the lipopolysaccharide (LPS) control mice. (F) Kallistatin treatment also significantly increased renal SOCS3 expression (n = 3 to 6). Data are expressed as means ± SE. *P <0.05 versus control group; # P <0.05 versus LPS control group.

Back to article page