Skip to main content

Table 2 Univariate and backwards multivariate linear regression analyses of associations between coagulopathy evaluated by TEG and biomarkers of endothelial activation and damage in 184 patients with severe sepsis

From: Association between biomarkers of endothelial injury and hypocoagulability in patients with severe sepsis: a prospective study

Variable Unit TEG R-time TEG Angle TEG MA FF MA
   β (SE) t P β (SE) t P β (SE) t P β (SE) t P
Univariate              
Syndecan-1 100 ng/ml 0.82 (0.24) 3 0.001 −3.06 (091) 3 0.001 −3.40 (0.79) −4 <0.001 −2.00 (0.64) −3 0.002
Thrombomodulin ng/ml 0.13 (0.06) 2 0.021 −0.49 (0.22) −2 0.026 −0.60 (0.19) −3 0.002 −0.58 (0.15) −4 <0.001
Protein C 10% −0.20 (0.10) −2 0.044 1.09 (0.37) 3 0.004 1.49 (0.32) 5 <0.001 1.05 (0.25) 4 <0.001
SOFA score point 0.30 (0.08) 4 <0.001 −1.25 (0.30) −4 <0.0001 −1.27 (0.26) −5 <0.001 - - NS
D-dimer mg FEU/l 0.03 (0.02) 2 0.044 −0.13 (0.06) −2 0.026 −0.13 (0.05) −3 0.011 −0.14 (0.04) −4 0.001
Owren type PT 10% −0.29 (0.12) −2 0.020 1.02 (0.46) 2 0.029 1.39 (0.40) 4 0.001 1.80 (0.30) 6 <0.001
P-fibrinogen g/l - - NS 1.41 (0.47) 3 0.003 2.62 (0.35) 7 <0.001 3.50 (0.18) 19 <0.001
Crystalloid 100 ml - - NS - - NS - - NS −0.10 (0.04) −2 0.022
Multivariate             
Syndecan-1 100 ng/ml 0.64 (0.25) 3 0.013 - - NS −1.78 (0.87) −2 0.042 −0.84 (0.42) −2 0.045
SOFA score point 0.23 (0.08) 3 0.006 −1.19 (0.30) −4 <0.001 −1.07 (0.27) −4 <0.001 Not included
D-dimer mg FEU/l - - NS - - NS - - NS - - NS
Owren type PT 10% - - NS - - NS 0.96 (0.40) 2 0.020 0.86 (0.23) 3 0.001
P-fibrinogen g/l Not included 1.26 (0.44) 3 0.004 - - NS 3.44 (0.21) 17 <0.001
Crystalloid 100 ml Not included Not included Not included - - NS
Multivariate              
Thrombomodulin ng/ml - - NS - - NS - - NS - - NS
SOFA score point 0.28 (0.08) 2 <0.001 −1.19 (0.30) −4 <0.001 −1.24 (0.26) −5 <0.001 Not included
D-dimer mg FEU/l - - NS - - NS - - NS - - NS
Owren type PT 10% −0.26 (0.12) −2 0.031 - - NS 1.27 (0.38) 3 <0.001 0.54 (0.20) 3 0.007
P-fibrinogen g/l Not included 1.26 (0.44) 3 0.004 - - NS 3.35 (0.21) 17 <0.001
Crystalloid 100 ml Not included Not included Not included - - NS
Multivariate              
Protein C 10% - - NS - - NS 1.24 (0.31) 4 <0.001 - - NS
SOFA score point 0.28 (0.08) 4 <0.001 −1.19 (0.30) −4 <0.001 −1.09 (0.26) −4 <0.001 Not included
D-dimer mg FEU/l - - NS - - NS - - NS - - NS
Owren type PT 10% −0.26 (0.19) −2 0.031 - - NS - - NS 0.54 (0.20) 3 0.007
P-fibrinogen g/l Not included 1.26 (0.44) 3 0.004 - - NS 3.35 (0.21) 17 <0.001
Crystalloid 100 ml Not included Not included Not included - - NS
  1. Regression coefficients (β) with standard errors (SE), t and P values displayed for the univariate and backwards selection multivariate models. Individual backwards multivariate linear regression models including only univariate significant variables, were applied for each investigated biomarker (syndecan-1, sTM and protein C). P values are shown in bold for endothelial-derived biomarkers with P <0.05. Predicted change in TEG R-time (minutes), TEG angle (degrees),TEG MA (maximum amplitude, mm) or FF MA (maximum amplitude, mm) associated with one unit increase in syndecan-1 (100 ng/ml), thrombomodulin (ng/ml), protein C (10%), SOFA score (point), D-dimer (mg FEU/l), Owren type PT (10%), plasma (p)-fibrinogen (g/l) and crystalloids administered in the 24 hours prior to blood sampling and randomization (100 ml).