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Table 1 Baseline (inclusion) characteristics, endothelial-derived biomarker levels, thrombelastography, transfusions during ICU stay and outcome in 184 patients with severe sepsis

From: Association between biomarkers of endothelial injury and hypocoagulability in patients with severe sepsis: a prospective study

   All
Variable   Median (IQR)
Age years 67 (59-75)
Male gender n (%) 101 (55%)
Disease severity   
Lactate mmol/l 2.2 (1.4-3.7)
SBP mmHg 82 (70-92)
SOFA score 8 (6-10)
SAPS score 56 (41-68)
Biochemistry   
Hemoglobin g/dl 9.5 (8.4-10.8)
White blood cells 109/l 12.3 (7.4-20.1)
Platelet count 109/l 133 (71-232)
Creatinine μmol/l 97 (62-172)
BUN μmol/l 10.5 (6.8-17.7)
Bilirubin μmol/l 12 (7-21)
D-dimer mg FEU/l 4.8 (2.2-9.6)
Owren type PT % 0.47 (0.34-0.61)
Plasma fibrinogen g/l 4.7 (3.4-6.5)
Endothelial biomarkers   
Syndecan-1 ng/ml 97 (51-204)
Thrombomodulin ng/ml 7.7 (5.2-10.8)
Protein C % 47.4 (33.5-66.4)
tPA ng/ml 16.4 (11.4-23.6)
PAI ng/ml 30.9 (19.3-39.5)
Thrombelastography (TEG)   
R-time min 7.7 (6.4-9.3)
Angle degrees 65 (55-71)
TEG MA mm 66 (58-72)
Ly30 % 0 (0.0-0.3)
Ly30 > 0% n (%) 65 (36%)
Functional fibrinogen (FF)   
FF MA mm 21.9 (16.1-28.8)
Transfusions in ICU   
RBC n (%) 119 (65%)
FFP n (%) 64 (35%)
Platelets n (%) 52 (28%)
Mortality   
7-day n (%) 39 (21%)
28-day n (%) 72 (39%)
90-day n (%) 98 (53%)
1-year n (%) 113 (61%)
  1. Data are presented as medians (IQR) or n (%). BUN, blood urea nitrogen; Emergency surgery, emergency surgery prior to ICU admission; FF MA, maximum amplitude in functional fibrinogen; FEU, fibrinogen equivalent units; FFP, fresh frozen plasma; Ly30, lysis 30 minutes after MA; Mortality; mortality of any cause; Owren type PT, reporting coagulation factor activity in percentage [41]; PAI-1, plasminogen activator inhibitor-1; R-time, reaction time; RBC, red blood cells; SAPS, simplified acute physiology score (calculated from 17 variables with higher scores indicating more severe disease, but without recording the cerebral component of the score); SBP, systolic blood pressure; SOFA, sequential organ failure assessment (sub-scores ranging from 0 to 4 for each of five components (circulation, lungs, liver, kidneys and coagulation, with aggregated scores ranging from 0 to 20, with higher scores indicating more severe organ failure); TEG MA, maximum amplitude in kaolin TEG; tPA, tissue-type plasminogen activator.