| | |
All
|
|---|
|
Variable
| |
Median (IQR)
|
|---|
|
Age
|
years
|
67 (59-75)
|
|
Male gender
|
n (%)
|
101 (55%)
|
|
Disease severity
| | |
|
Lactate
|
mmol/l
|
2.2 (1.4-3.7)
|
|
SBP
|
mmHg
|
82 (70-92)
|
|
SOFA
|
score
|
8 (6-10)
|
|
SAPS
|
score
|
56 (41-68)
|
|
Biochemistry
| | |
|
Hemoglobin
|
g/dl
|
9.5 (8.4-10.8)
|
|
White blood cells
|
109/l
|
12.3 (7.4-20.1)
|
|
Platelet count
|
109/l
|
133 (71-232)
|
|
Creatinine
|
μmol/l
|
97 (62-172)
|
|
BUN
|
μmol/l
|
10.5 (6.8-17.7)
|
|
Bilirubin
|
μmol/l
|
12 (7-21)
|
|
D-dimer
|
mg FEU/l
|
4.8 (2.2-9.6)
|
|
Owren type PT
|
%
|
0.47 (0.34-0.61)
|
|
Plasma fibrinogen
|
g/l
|
4.7 (3.4-6.5)
|
|
Endothelial biomarkers
| | |
|
Syndecan-1
|
ng/ml
|
97 (51-204)
|
|
Thrombomodulin
|
ng/ml
|
7.7 (5.2-10.8)
|
|
Protein C
|
%
|
47.4 (33.5-66.4)
|
|
tPA
|
ng/ml
|
16.4 (11.4-23.6)
|
|
PAI
|
ng/ml
|
30.9 (19.3-39.5)
|
|
Thrombelastography (TEG)
| | |
|
R-time
|
min
|
7.7 (6.4-9.3)
|
|
Angle
|
degrees
|
65 (55-71)
|
|
TEG MA
|
mm
|
66 (58-72)
|
|
Ly30
|
%
|
0 (0.0-0.3)
|
|
Ly30 > 0%
|
n (%)
|
65 (36%)
|
|
Functional fibrinogen (FF)
| | |
|
FF MA
|
mm
|
21.9 (16.1-28.8)
|
|
Transfusions in ICU
| | |
|
RBC
|
n (%)
|
119 (65%)
|
|
FFP
|
n (%)
|
64 (35%)
|
|
Platelets
|
n (%)
|
52 (28%)
|
|
Mortality
| | |
|
7-day
|
n (%)
|
39 (21%)
|
|
28-day
|
n (%)
|
72 (39%)
|
|
90-day
|
n (%)
|
98 (53%)
|
|
1-year
|
n (%)
|
113 (61%)
|
- Data are presented as medians (IQR) or n (%). BUN, blood urea nitrogen; Emergency surgery, emergency surgery prior to ICU admission; FF MA, maximum amplitude in functional fibrinogen; FEU, fibrinogen equivalent units; FFP, fresh frozen plasma; Ly30, lysis 30 minutes after MA; Mortality; mortality of any cause; Owren type PT, reporting coagulation factor activity in percentage [41]; PAI-1, plasminogen activator inhibitor-1; R-time, reaction time; RBC, red blood cells; SAPS, simplified acute physiology score (calculated from 17 variables with higher scores indicating more severe disease, but without recording the cerebral component of the score); SBP, systolic blood pressure; SOFA, sequential organ failure assessment (sub-scores ranging from 0 to 4 for each of five components (circulation, lungs, liver, kidneys and coagulation, with aggregated scores ranging from 0 to 20, with higher scores indicating more severe organ failure); TEG MA, maximum amplitude in kaolin TEG; tPA, tissue-type plasminogen activator.
