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Table 2 T0, T1, T2 and peak urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 concentrations by serum creatinine-based RIFLE status within 48 hours following admissiona

From: Urinary neutrophil gelatinase-associated lipocalin identifies critically ill young children with acute kidney injury following intensive care admission: a prospective cohort study

Measurement, number of patients Non-AKI, n = 65 RIFLE-Risk, n = 15 RIFLE-Injury, n = 10 RIFLE-Failure, n = 10 P -value
T0, 0 to 6 hr      
  uNGAL (ng/ml), n = 59 31 (16 to 111) 396 (70to 1,250) 385 (77 to 1,987) 1,873 (484 to 3,936) <0.001
  KIM-1 (ng/ml), n = 59 0.11 (0.08 to 0.19) 0.18 (0.13 to 0.28) 0.10 (0.08 to 0.11) 1.2 (0.4 to 3.5) 0.004
T1, 6 to 12 hr      
  uNGAL (ng/ml), n = 85 21 (8 to 116) 114 (61 to 420) 275 (11 to 4630) 2430 (727 to 6000) <0.001
  KIM-1 (ng/ml), n = 85 0.11 (0.08 to 0.27) 0.10 (0.08 to 0.29) 0.12 (0.08 to 0.16) 0.35 (0.29 to 1.21) 0.018
T2, 12 to 24 hr      
  uNGAL (ng/ml), n = 95 22 (10 to 98) 34 (22 to 200) 47 (26 to 1935) 979 (301 to 6000) 0.001
  KIM-1 (ng/ml), n = 93 0.16 (0.08 to 0.28) 0.26 (0.11 to 0.56) 0.30 (0.12 to 0.41) 0.47 (0.26 to 2.15) 0.002
24-hr peak level      
  uNGAL (ng/ml), n = 100 59 (16 to 136) 225 (89 to 730) 385 (56 to 3938) 1495 (387 to 6000) <0.001
  KIM-1 (ng/ml), n = 100 0.17 (0.08 to 0.34) 0.26 (0.11 to 0.56) 0.25 (0.10 to 0.41) 0.86 (0.44 to 2.15) 0.001
  1. aAKI, Acute kidney injury; KIM-1, Kidney injury molecule-1; RIFLE, Risk, injury, failure, loss, end-stage renal disease; SCr, Serum creatinine; uNGAL, Urinary neutrophil gelatinase-associated lipocalin. Data are expressed as median (interquartile range). P-values indicate overall comparison of all groups (that is, non-AKI versus Risk versus Injury versus Failure). Intergroup differences were assessed using the Kruskal-Wallis test. RIFLE categories risk, injury and failure were defined as, respectively, serum creatinine (SCr) above 150%, 200% and 300% of the median age-specific SCr reference values.