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Table 3 Comparison of Aspergillus-specific lateral-flow device test and conventional bronchoalveolar lavage culture performance for diagnosing probable or proven versus no invasive pulmonary aspergillosisa

From: Multicenter evaluation of a lateral-flow device test for diagnosing invasive pulmonary aspergillosis in ICU patients

Probable or proven IPA versus no IPA LFD Conventional BAL culture
Sensitivity 80% (16/20) 50% (10/20)
Specificity 81% (88/108) 85% (88/103)
PPV 44% (16/36) 40% (10/25)
NPV 96% (88/92) 90% (88/98)
DOR (95% CI) 17.6 (5.3 to 58.3) 5.9 (2.1 to 16.5)
  1. aBAL, Bronchoalveolar lavage; CI, Confidence interval; DOR, Diagnostic odds ratio; IPA, Invasive pulmonary aspergillosis; LFD, Aspergillus-specific lateral-flow device test; NPV, Negative predictive value; PPV, Positive predictive value. According to European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria [34], probable IPA cases require mycological evidence by positive Aspergillus spp BAL culture, cytology, microscopy or positive galactomannan tests, in addition to host factors and clinical criteria.