Parameters
|
PFO and ACP
|
PFO only
|
ACP only
|
No PFO and no ACP
|
P
value
|
---|
|
(n = 8)
|
(n = 21)
|
(n = 36)
|
(n = 130)
| |
---|
VT/predicted body weight (mL/kg)
|
6.5 [5; 7]
|
6 [5; 7]
|
6.5 [6; 8]
|
6 [5; 7]
|
0.64
|
PEEP (cmH2O)
|
10 [6; 13]
|
10 [8; 12]
|
10 [8; 14]
|
11 [8; 12]
|
0.36
|
Driving pressure (cmH2O)b
|
15 [13; 16]
|
16 [13; 17]
|
15 [12; 20]
|
14 [11; 17]
|
0.22
|
PaO2/FiO2
|
95 [75; 115]
|
107 [71; 153]
|
114 [72; 145]
|
112 [91; 154]
|
0.33
|
PaCO2 (mmHg)
|
47 [40; 62]
|
48 [41; 52]
|
50 [44; 58]
|
45 [39; 53]
|
0.28
|
Heart rate (bpm)
|
106 [91; 116]
|
105 [97; 128]
|
97 [85; 113]
|
100 [85; 116]
|
0.29
|
mBP (mmHg)
|
79 [70; 85]
|
79 [70; 89]
|
80 [74; 88]
|
81 [73; 90]
|
0.80
|
CVP (mmHg)
|
11 [10; 13]
|
11 [10; 12]
|
11 [10; 14]
|
10 [9; 12]
|
0.96
|
Lactates (mmol/L)
|
1.3 [1.2; 1.9]
|
1.3 [1; 2]
|
1.3 [1; 2.1]
|
1.4 [1.1; 2]
|
0.93
|
Prone positioning (n)
|
2 (25%)
|
3 (14%)
|
18 (50%)
|
44 (34%)
|
0.04
|
Nitric oxide (n)
|
3 (38%)
|
2 (10%)
|
6 (17%)
|
14 (11%)
|
0.15
|
Vasopressor support (n)
|
6 (75%)
|
10 (48%)
|
18 (50%)
|
62 (48%)
|
0.55
|
28-day mortality (n)
|
1 (13%)
|
6 (29%)
|
9 (25%)
|
29 (22%)
|
0.82
|
-
aResults are expressed as median values with 25th to 75th percentiles unless otherwise stated; bdefined as the difference between the inspiratory plateau pressure and positive end-expiratory pressure. ACP, acute cor pulmonale; PFO, patent foramen ovale; VT, tidal volume; PEEP, positive end-expiratory pressure; PaO2, partial pressure of arterial oxygen; FiO2, fraction of inspired oxygen; PaCO2, partial pressure of arterial carbon dioxide; mBP, mean blood pressure; CVP, central venous pressure.