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Table 1 Respiratory and hemodynamic variables according to the presence or absence of ACP and/or PFOa

From: Acute respiratory distress syndrome (ARDS)-associated acute cor pulmonale and patent foramen ovale: a multicenter noninvasive hemodynamic study

Parameters PFO and ACP PFO only ACP only No PFO and no ACP P value
  (n = 8) (n = 21) (n = 36) (n = 130)  
VT/predicted body weight (mL/kg) 6.5 [5; 7] 6 [5; 7] 6.5 [6; 8] 6 [5; 7] 0.64
PEEP (cmH2O) 10 [6; 13] 10 [8; 12] 10 [8; 14] 11 [8; 12] 0.36
Driving pressure (cmH2O)b 15 [13; 16] 16 [13; 17] 15 [12; 20] 14 [11; 17] 0.22
PaO2/FiO2 95 [75; 115] 107 [71; 153] 114 [72; 145] 112 [91; 154] 0.33
PaCO2 (mmHg) 47 [40; 62] 48 [41; 52] 50 [44; 58] 45 [39; 53] 0.28
Heart rate (bpm) 106 [91; 116] 105 [97; 128] 97 [85; 113] 100 [85; 116] 0.29
mBP (mmHg) 79 [70; 85] 79 [70; 89] 80 [74; 88] 81 [73; 90] 0.80
CVP (mmHg) 11 [10; 13] 11 [10; 12] 11 [10; 14] 10 [9; 12] 0.96
Lactates (mmol/L) 1.3 [1.2; 1.9] 1.3 [1; 2] 1.3 [1; 2.1] 1.4 [1.1; 2] 0.93
Prone positioning (n) 2 (25%) 3 (14%) 18 (50%) 44 (34%) 0.04
Nitric oxide (n) 3 (38%) 2 (10%) 6 (17%) 14 (11%) 0.15
Vasopressor support (n) 6 (75%) 10 (48%) 18 (50%) 62 (48%) 0.55
28-day mortality (n) 1 (13%) 6 (29%) 9 (25%) 29 (22%) 0.82
  1. aResults are expressed as median values with 25th to 75th percentiles unless otherwise stated; bdefined as the difference between the inspiratory plateau pressure and positive end-expiratory pressure. ACP, acute cor pulmonale; PFO, patent foramen ovale; VT, tidal volume; PEEP, positive end-expiratory pressure; PaO2, partial pressure of arterial oxygen; FiO2, fraction of inspired oxygen; PaCO2, partial pressure of arterial carbon dioxide; mBP, mean blood pressure; CVP, central venous pressure.