Acute respiratory distress syndrome (ARDS)-associated acute cor pulmonale and patent foramen ovale: a multicenter noninvasive hemodynamic study

Table 1 Respiratory and hemodynamic variables according to the presence or absence of ACP and/or PFO^a

Parameters	PFO and ACP	PFO only	ACP only	No PFO and no ACP	P value
	(n = 8)	(n = 21)	(n = 36)	(n = 130)
V_T/predicted body weight (mL/kg)	6.5 [5; 7]	6 [5; 7]	6.5 [6; 8]	6 [5; 7]	0.64
PEEP (cmH₂O)	10 [6; 13]	10 [8; 12]	10 [8; 14]	11 [8; 12]	0.36
Driving pressure (cmH₂O)^b	15 [13; 16]	16 [13; 17]	15 [12; 20]	14 [11; 17]	0.22
PaO₂/FiO₂	95 [75; 115]	107 [71; 153]	114 [72; 145]	112 [91; 154]	0.33
PaCO₂ (mmHg)	47 [40; 62]	48 [41; 52]	50 [44; 58]	45 [39; 53]	0.28
Heart rate (bpm)	106 [91; 116]	105 [97; 128]	97 [85; 113]	100 [85; 116]	0.29
mBP (mmHg)	79 [70; 85]	79 [70; 89]	80 [74; 88]	81 [73; 90]	0.80
CVP (mmHg)	11 [10; 13]	11 [10; 12]	11 [10; 14]	10 [9; 12]	0.96
Lactates (mmol/L)	1.3 [1.2; 1.9]	1.3 [1; 2]	1.3 [1; 2.1]	1.4 [1.1; 2]	0.93
Prone positioning (n)	2 (25%)	3 (14%)	18 (50%)	44 (34%)	0.04
Nitric oxide (n)	3 (38%)	2 (10%)	6 (17%)	14 (11%)	0.15
Vasopressor support (n)	6 (75%)	10 (48%)	18 (50%)	62 (48%)	0.55
28-day mortality (n)	1 (13%)	6 (29%)	9 (25%)	29 (22%)	0.82

^aResults are expressed as median values with 25^th to 75^th percentiles unless otherwise stated; ^bdefined as the difference between the inspiratory plateau pressure and positive end-expiratory pressure. ACP, acute cor pulmonale; PFO, patent foramen ovale; VT, tidal volume; PEEP, positive end-expiratory pressure; PaO2, partial pressure of arterial oxygen; FiO2, fraction of inspired oxygen; PaCO2, partial pressure of arterial carbon dioxide; mBP, mean blood pressure; CVP, central venous pressure.

ISSN: 1364-8535