A pilot study of change in fracture risk in patients with acute respiratory distress syndrome

Rawal, Jaikitry; McPhail, Mark JW; Ratnayake, Gamumu; Chan, Pearl; Moxham, John; Harridge, Stephen DR; Hart, Nicholas; Montgomery, Hugh E; Puthucheary, Zudin A

doi:10.1186/s13054-015-0892-y

Critical Care

Table 2 Bivariable and multivariable logistical analysis of bedside physiology versus 2% loss of bone mineral density by day 10

From: A pilot study of change in fracture risk in patients with acute respiratory distress syndrome

		Univariate			Multivariate
Variable	OR	95% CI	P value	OR	95% CI	P value
Admission BMD	1.000	0.997-1.003	0.899
Change in RF_CSA	1.019	0.971-1.070	0.439
Organ failure	1.078	1.005-1.157	0.037^g
Age	0.980	0.946-1.015	0.268	0.977	0.939-1.059	0.935
CRP^a	1.000	0.999-1.001	0.857
Chronic disease^e	1.385	0.417-4.602	0.595	1.266	0.167-9.596	0.819
Insulin^a,b	1.046	0.937-1.167	0.421
Protein^a,b	1.034	0.941-1.136	0.491
Calories^a,b	1.007	0.996-1.017	0.220
LMWH^f	1.001	0.998-1.004	0.530
Unfractionated heparin^f	1.000	1.000-1.000	0.518
All heparin^f	1.000	1.000-1.000	0.725
Male sex	1.711	0.499-5.871	0.393	4.966	0.567-43.567	0.147
APACHE II	1.050	0.937-1.176	0.403
SAPS II	0.995	0.944-1.050	0.867
Admission SOFA	1.080	0.846-1.381	0.536
Temperature	0.788	0.489-1.270	0.328
Haemoglobin	1.047	0.794-1.381	0.744
White cell count	0.886	0.778-1.009	0.068
Platelets	0.994	0.988-1.000	0.053
INR	4.960	0.886-27.774	0.068
APTTR	2.830	0.403-19.873	0.296
Sodium	0.988	0.871-1.121	0.856
Potassium	0.475	0.160-1.411	0.180
Urea	0.999	0.891-1.121	0.992
Creatinine	1.001	0.990-1.011	0.914
Alkaline phosphatase	1.010	0.995-1.025	0.178
AST	1.003	0.999-1.006	0.097
Bilirubin	1.048	0.998-1.101	0.061	1.078	0.994-1.156	0.076
Albumin	1.027	0.944-1.117	0.539
Calcium^g	1.974	1.116-3.492	0.020^g	1.980	1.089-3.609	0.026
Phosphate	0.653	0.195-2.191	0.491
Magnesium	0.435	0.036-5.190	0.510
PaO₂	0.836	0.659-1.061	0.141
SaO₂	0.840	0.617-1.145	0.271
PaCO₂	0.943	0.600-1.482	0.798
H⁺	1.000	0.993-1.006	0.960
Base excess	0.967	0.812-1.151	0.706
Bicarbonate	1.024	0.839-1.249	0.815
Lactate	1.018	0.669-1.549	0.933
Chloride	1.047	.0935-1.172	0.424
Apparent SID	0.914	.0792-1.055	0.218
Effective SID	0.641	0.933-1.118	0.641
Strong ion gap	0.968	0.905-1.035	0.338
Glucose day 1	0.923	0.622-1.370	0.692
MAP	1.010	0.947-1.077	0.768
Heart rate	0.994	0.960-1.029	0.735
PaO₂ /FiO₂ ratio	0.943	0.890-1.000	0.050^g	0.916	0.833-0.998	0.044
SIRS	0.544	0.154-1.925	0.345
NMB use	1.154	0.742-1.795	0.524
Corticosteroid use^c	1.000	1.000-1.001	0.856
RRT	1.094	0.291-4.109	0.894
HMGCoA use^d	2.000	0.483-8.275	0.339
Median glucose^a	1.158	0.637-2.104	0.631
Days of intubation	0.988	0.923-1.057	0.724
LOS pre-admission	1.166	0.681-1.994	0.576

Organ failure was defined by SOFA scoring. All values are for day 1 of ICU admission, except ^awhich denotes area under curve for 10 days. ^bIndicates those normalised to ideal body weight. ^cCorticosteroid doses calculated in hydrocortisone equivalents. ^dDenotes use on admission, and continued through study period. ^eChronic disease defined by hospital and general practice coding for management of chronic disease. ^fIndicates cumulative dose. ^gcalcium variable, exponentially transformed to allow logistic regression. Bold type indicates P <0.05.
APACHE II = Acute Physiology and Chronic Health Evaluation II score, APTTR = Activated partial thromboplastin time ratio, AST = Aspartate transaminase, CRP = C-reactive protein, FiO₂ = Fraction of inspired oxygen, HMGCoA RI = 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitor treatment, INR = International normalised ratio, LMWH = Low molecular weight heparin, LOS = Length of stay, NMB = Neuromuscular blockade, PaCO₂ = Partial pressure of carbon dioxide in arterial blood, PaO₂ = Partial pressure of oxygen in arterial blood, RF_CSA = Rectus Femoris cross-sectional area in 10 days, RRT = Renal replacement therapy, SaO₂ = Oxygen saturation in arterial blood, SAPS 2 = Simplified Acute Physiology Score 2, SID = Strong Ion Difference, SOFA = Sequential Organ Failure Assessment.

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ISSN: 1364-8535

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