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Table 2 Outcomes of included trials on fish oil strategies using lipid emulsions a

From: Intravenous fish oil lipid emulsions in critically ill patients: an updated systematic review and meta-analysis

Study LOS in days Ventilator days Other  
FO
Grecu et al ., 2003 b [62] Omegaven (Fresenius Kabi, Bad Homburg, Germany) LCT Omegaven LCT Omegaven LCT
ICU ICU 2.83 ± 1.62 (8) 5.23 ± 2.80 (7) Patients undergoing reoperation for septic episode
3.32 ± 1.48 (8) 9.28 ± 3.08 (7) 2/28 (7) 8/26 (31)
Hospital Hospital
11.68 ± 2.04 (28) 20.46 ± 3.27 (26)
Friesecke et al ., 2008 [63] FO LCT LCT + MCT + FO LCT + MCT LCT + MCT + FO LCT + MCT
ICU ICU 22.8 ± 22.9 (83) 20.5 ± 19.0 (82) Urinary tract infections
28 ± 25 (83) 23 ± 20 (82) 6/83 (7) 4/82 (5)
Catheter-related infections
1/83 (1) 3/83 (4)
Total EN energy intake (kcal/kg)
22.2 ± 5.5 21.6 ± 5.6
Wang et al ., 2009 [61] NR NR NR NR Omegaven LCT
Surgery of infected pancreatic necrosis
3/28 (11) 6/28 (21)
Barbosa et al ., 2010 [64] MCT + LCT + FO MCT + LCT MCT + LCT + FO MCT + LCT MCT + LCT+ FO MCT + LCT
ICU ICU 10 ± 14.4 (13) 11 ± 12.64 (10) 2,057 ± 418 kcal 1,857 ± 255 kcal
12 ± 14.4c (13) 13 ± 12.6c (10)
Hospital Hospital
22 ± 25.2c (13) 55 ± 50.6c (10)
Gupta et al ., 2011 [15] Omegaven Standard EN Omegaven Standard EN   
ICU ICU 11.78 ± 10.63 (31) 10.71 ± 14.55 (30)
15.96 ± 7.57 (31) 15.88 ± 6.47 (30)
Hospital Hospital
21.5 ± 13.49 (31) 26.63 ± 18.22 (30)
Khor et al ., 2011 [16] Omegaven Saline Omegaven Saline   
ICU ICU 13.0 ± 10.1 (9) 11.6 ± 9.5 (5)
10.3 ± 8.4 (14) 8.4 ± 6.5 (13)
Hospital Hospital
19.6 ± 7.4 (14) 17.5 ± 6.0 (13)
Burkhart et al ., 2013 [18] Omegaven No Omegaven NR NR Omegaven No Omegaven
ICU ICU Subsyndromal delirium
5 (3 to 22) 6 (2 to 33) 5 (25) 6 (29)
Sepsis associated delirium
15 (75) 15 (71)
Grau-Carmona et al ., 2014 [65] MCT + LCT + FO MCT + LCT MCT + LCT + FO MCT + LCT MCT + LCT+ FO MCT + LCT
ICU ICU 8.41 ± 6.61 9.2 ± 6.0 Parenteral lipid intake [(g/kg BW)/d]
18.9 ± 15.5 21.8 ± 20.9 1.04 ± 0.12 1.05 ± 0.13
Hospital Hospital PN kcal
41.1 ± 41.0 42.5 ± 28.5 1,737 ± 353 1,782 ± 312
Gultekin et al ., 2014 [66] Omegaven + olive Olive oil NR NR Omegaven + olive oil Olive oil
Hospital Hospital  
31.6 ± 4.3 30.6 ± 4.3 27.5 ± 1.5 kcal/kg/day 15.8 ± 1.5 kcal/kg/day
1.3 ± 0.2 g protein/kg/day 1.1 ± 0.1 g protein/kg/day
Hall et al ., 2014 [17] Omegaven No Omegaven NR (reported as free ventilator days) NR (reported as free ventilator days)   
ICU ICU   
8.8 ± 7.7 12.3 ± 12.4
Hospital Hospital
26.7 ± 18.2 33.5 ± 30.4
  1. aThese studies compared fish oil (ω-3)–containing emulsions in parenteral nutrition–fed patients vs. LCT or LCT + MCT. EN, Enteral nutrition; FO, Fish oil; ICU, Intensive care unit; LCT, Long-chain triglycerides; MCT, Medium-chain triglycerides; ITT, Intention to treat; NR, Not reported. bData obtained from author, 8 of 28 in Omegaven (Fresenius Kabi, Bad Homburg, Germany) group and 7 of 26 in LCT group were in the ICU. cConverted standard error of the mean to standard deviation.