|
Analyte
|
Control
|
Severe sepsis
|
Fold increase
|
P
value
|
|---|
|
MCP-1
|
41.8 ± 12.1
|
1067.8 ± 196.4
|
25
|
<0.001
|
|
G-CSF
|
29.3 ± 9.5
|
938.4 ± 278.5
|
32
|
<0.001
|
|
IL-8
|
10.0 ± 0.0
|
211.9 ± 43.4
|
21
|
<0.001
|
|
HGF
|
290.3 ± 60.8
|
3346.8 ± 570.5
|
12
|
<0.001
|
|
MIP-1β
|
49.7 ± 12.1
|
381.1 ± 116.0
|
8
|
<0.001
|
|
IP-10
|
214.4 ± 26.8
|
1552.0 ± 254.5
|
7
|
<0.001
|
|
GROα
|
92.5 ± 24.2
|
637.5 ± 136.3
|
7
|
<0.001
|
|
IL-6
|
80.8 ± 31.8
|
387.6 ± 158.4
|
5
|
0.017
|
- Plasma was obtained from severe sepsis patients and compared to plasma from age- and sex-matched healthy controls. Analytes were measured with antibody microarray and presented as mean ± SE. Values are in ng/mL (n = 20 per group). MCP-1-monocyte chemotactic protein-1; GCSF-granulocyte colony-stimulating factor; IL-8- interleukin-8; HGF- hepatocyte growth factor; MIP-1β- macrophage inflammatory protein-1 beta; IP-10- interferon-inducible protein 10 kDa; GRO-α- growth-regulated oncogene alpha; IL-6- interleukin-6.
