Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro

Table 2 Plasma concentration of inflammatory analytes used to make the control and severe sepsis cytokine mixtures

Analyte	Control	Severe sepsis	Fold increase	P value
MCP-1	41.8 ± 12.1	1067.8 ± 196.4	25	<0.001
G-CSF	29.3 ± 9.5	938.4 ± 278.5	32	<0.001
IL-8	10.0 ± 0.0	211.9 ± 43.4	21	<0.001
HGF	290.3 ± 60.8	3346.8 ± 570.5	12	<0.001
MIP-1β	49.7 ± 12.1	381.1 ± 116.0	8	<0.001
IP-10	214.4 ± 26.8	1552.0 ± 254.5	7	<0.001
GROα	92.5 ± 24.2	637.5 ± 136.3	7	<0.001
IL-6	80.8 ± 31.8	387.6 ± 158.4	5	0.017

Plasma was obtained from severe sepsis patients and compared to plasma from age- and sex-matched healthy controls. Analytes were measured with antibody microarray and presented as mean ± SE. Values are in ng/mL (n = 20 per group). MCP-1-monocyte chemotactic protein-1; GCSF-granulocyte colony-stimulating factor; IL-8- interleukin-8; HGF- hepatocyte growth factor; MIP-1β- macrophage inflammatory protein-1 beta; IP-10- interferon-inducible protein 10 kDa; GRO-α- growth-regulated oncogene alpha; IL-6- interleukin-6.

ISSN: 1364-8535