Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro

Table 1 Baseline characteristics of 20 patients with severe sepsis on ICU day 1

Age, years	59 ± 4 (20-80)
Gender, female	6 (30%)
APACHE II score	25.8 ± 2.1 (6-42)
MOD score	10.4 ± 0.86 (3-15)
Absolute neutrophil count (ANC)^a	11.5 ± 0.9 (3.7-19.5)
*Co-morbidities, number (% of total)*
Cardiovascular	9 (45%)
Pulmonary	5 (25%)
Hepatitis/pancreatitis	5 (25%)
Inflammatory	3 (15%)
Neurological	3 (15%)
Renal	3 (15%)
Diabetes	2 (10%)
*Primary site of infection, number (% of total)*
Lung	11 (55%)
Abdomen	3 (15%)
Blood	1 (5%)
Urinary Tract	0 (0%)
Other	4 (20%)
Unknown	1 (5%)
*Total number of positive cultures (% of total)*^b
Gram-negative bacteria	10 (50%)
Gram-positive bacteria	9 (45%)
Fungus	2 (10%)

Data are presented as mean ± SE (range) or n (%). ^aNormal ANC = 1.5-8.0. ^bIncludes blood and non-blood cultures, therefore the total is >100%. Four poly-microbial non-blood cultures were not included in the table. APACHE II, Acute Physiology and Chronic Health Evaluation II; MOD, Multiple organ dysfunction.